Aldosterone antagonists

An aldosterone antagonist blocks the effects of the stress hormone aldosterone. When your body makes too much aldosterone, it causes your kidneys keep more sodium and water.

An aldosterone antagonist may help you live longer and reduce your hospital stays.

The aldosterone antagonists used for heart failure are:

  • spironolactone (Aldactone®)
  • eplerenone (Inspra®)

Side effects

Possible side effects include:

  • increased potassium levels. Your health care provider will make sure your potassium level is normal with blood tests.
  • enlarged breasts or tenderness in men and women.
  • sexual issues, such as impotence or decrease in sexual drive.

Source: Allina Health's Patient Education Department, Heart Failure, fifth edition, 1-931876-20-7
First Published: 10/04/2002
Last Reviewed: 05/01/2015