Health Guide
Drug Guide

Carfilzomib (Intravenous route)

Pronunciation:

kar-FILZ-oh-mib

Brand Names:

Dosage Forms:

Classifications:

Therapeutic

Antineoplastic Agent

Pharmacologic

Proteasome Inhibitor

Uses of This Medicine:

Carfilzomib injection is used alone or together with other medicines (eg, dexamethasone, lenalidomide) to treat multiple myeloma (a type of bone marrow cancer) in patients who have received other treatments that did not work well. It interferes with the growth of cancer cells, which are eventually destroyed by the body. Carfilzomib is an antineoplastic agent (cancer medicine).

This medicine is to be given only by or under the supervision of your doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, carfilzomib is used in certain patients with the following medical conditions:

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children

Appropriate studies have not been performed on the relationship of age to the effects of carfilzomib injection in the pediatric population. Safety and efficacy have not been established.

Older adults

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of carfilzomib injection in the elderly.

Breast-feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine in a hospital or cancer clinic. This medicine is given through a needle placed in a vein.

This medicine needs to be given on a fixed schedule. Be sure to keep all appointments.

Drink extra fluids so you will pass more urine while you are receiving this medicine. This may help prevent kidney problems and other unwanted effects.

You might also receive medicines (eg, dexamethasone) to help prevent unwanted reactions to the injection.

Precautions While Using This Medicine:

It is very important that your doctor check you at regular visits while you are receiving this medicine to make sure that the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control during treatment and for at least 30 days after the last dose to keep from getting pregnant. Male patients must also use an effective form of birth control to prevent pregnancy in a sexual partner during treatment and for at least 90 days after the last dose. If you think a pregnancy has occurred with this medicine, tell your doctor right away.

This medicine may cause serious heart problems. Tell your doctor right away if you have chest pain or discomfort, shortness of breath, irregular heartbeats, or swelling of the feet, ankles, or legs while you are receiving this medicine.

Kidney problems may occur while you are receiving this medicine. Tell your doctor if you have the following symptoms: agitation, confusion, decreased urine output, depression, headache, rapid weight gain, swelling the face, ankles, or hands, or unusual tiredness or weakness.

This medicine may cause a serious reaction called tumor lysis syndrome (TLS). Call your doctor right away if you have a change in how much or how often you urinate, rapid weight gain, muscle or joint pain, swelling of the feet or lower legs, or feel tired.

Blood clots may occur while you are receiving this medicine. Tell your doctor right away if you have chest pain, dizziness or lightheadedness, fainting, fast heartbeat, pain, redness, or swelling in the arm or legs, sudden shortness of breath, trouble breathing.

This medicine may cause you to be more dizzy, lightheaded, or tired than normal. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Getting up slowly from a sitting or lying position may help prevent lightheadedness or dizziness. Tell your doctor if you feel dizzy or lightheaded.

This medicine may cause a serious type of allergic reaction called an infusion reaction. This can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a cough, difficulty with swallowing, dizziness, a fast heartbeat, chest tightness, trouble breathing, swelling in your face or hands, a fever, chills, itching or hives, or lightheadedness or faintness while you are receiving this medicine.

This medicine can lower the number of platelets in your blood, which are needed for blood clotting. Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, or pinpoint red spots on your skin.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Tell your doctor right away if you have seizures, headache, confusion, vision problems, unusual drowsiness, tiredness, or weakness. These could be symptoms of a serious nervous system problem called posterior reversible encephalopathy syndrome (PRES).

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Agitation
black, tarry stools
bleeding gums
bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine or stools
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain
coma
confusion
cough or hoarseness
decreased urine output
depression
difficult or labored breathing
difficulty with moving
dizziness
drowsiness
fast or irregular heartbeat
headache
hostility
irregular heartbeat
irritability
lethargy
lower back or side pain
muscle spasms (tetany) or twitching
nausea or vomiting
numbness or tingling in the hands, feet, or lips
painful or difficult urination
pale skin
pinpoint red spots on the skin
pounding in the ears
rapid weight gain
seizures
slow or fast heartbeat
stupor
tightness in the chest
tingling of the hands or feet
trembling
troubled breathing with exertion
ulcers, sores, or white spots in the mouth
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
Less common
Chills
fever
muscle pain or cramps
painful blisters on the trunk of the body
weakness in the arms, hands, legs, or feet
Rare
Dark-colored urine
general feeling of discomfort or illness
general feeling of tiredness or weakness
light-colored stools
stomach pain, continuing
thickening of bronchial secretions
yellow eyes or skin
Incidence not known
Blindness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
joint pain, stiffness, or swelling
seizures
stomach pain
sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Back pain
body aches or pain
bone pain
constipation
diarrhea
dry mouth
ear congestion
flushed, dry skin
fruit-like breath odor
increased hunger
increased thirst
increased urination
loss of appetite
loss of voice
metallic taste
muscle weakness
pain in the arms or legs
runny nose
sneezing
sore throat
trouble sleeping
weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/15/2016

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