Health Guide
Drug Guide

Cefotaxime (Injection route)

Pronunciation:

sef-oh-TAX-eem

Brand Names:

Dosage Forms:

Classifications:

Therapeutic

Antibiotic

Pharmacologic

3rd Generation Cephalosporin

Uses of This Medicine:

Cefotaxime injection is used to treat bacterial infections in many different parts of the body. This medicine is also given before, during, and after certain types of surgery to prevent infections.

Cefotaxime injection belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is to be given only by or under the supervision of your doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of cefotaxime injection in children.

Older adults

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cefotaxime injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving cefotaxime injection.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Other interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper Use of This Medicine:

A nurse or other trained health professional will give you or your child this medicine. This medicine is given as a shot into a muscle or a vein.

Precautions While Using This Medicine:

Your doctor will check your or your child's progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Cefotaxime injection may cause diarrhea, and in some cases it can be severe. Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Cefotaxime injection can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

Before you or your child have any medical tests, tell the medical doctor in charge that you are receiving this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common
Abdominal or stomach cramps or tenderness
black, tarry stools
bloating
chest pain
chills
diarrhea
diarrhea, watery and severe, which may also be bloody
difficulty with breathing
difficulty with swallowing
dizziness
fast heartbeat
fever
hives, itching, or skin rash
increased thirst
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
nausea or vomiting
noisy breathing
pain
painful or difficult urination
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
sore throat
sores, ulcers, or white spots on the lips or in the mouth
swollen glands
tenderness
tightness in the chest
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight loss
Rare
Agitation
back, leg, or stomach pains
bleeding gums
blistering, peeling, or loosening of the skin
blood in the urine or stools
bloody or cloudy urine
blurred vision
coma
confusion
cough or hoarseness
cracks in the skin at the corners of the mouth
dark urine
drowsiness
fainting
fast, slow, or irregular heartbeat
fever with or without chills
general body swelling
general feeling of tiredness or weakness
greatly decreased frequency of urination or amount of urine
hallucinations
headache
irritability
itching of the vagina or genital area
joint or muscle pain
loss of appetite
lower back or side pain
nosebleeds
pain during sexual intercourse
pale skin
pinpoint red spots on the skin
red skin lesions, often with a purple center
red, irritated eyes
seizures
soreness or redness around the fingernails and toenails
stiff neck
swelling of the feet or lower legs
thick, white vaginal discharge with no odor or with a mild odor
yellow eyes or skin
Incidence not known
Clay-colored stools
unpleasant breath odor
vomiting of blood

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Red streaks on the skin
swelling, tenderness, or pain at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/15/2016

Thomson Micromedex. All rights reserved.

Thomson & A.D.A.M