Health Guide
Drug Guide

Cefpodoxime (Oral route)


sef-poe-DOX-eem PROX-e-til

Brand Names:

Dosage Forms:





3rd Generation Cephalosporin

Uses of This Medicine:

Cefpodoxime is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of cefpodoxime in children. However, safety and efficacy have not been established in infants younger than 2 months of age.

Older adults

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cefpodoxime in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving cefpodoxime.


Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Other interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper Use of This Medicine:

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You or your child must take the tablets with food, while the oral liquid may be taken with or without food.

Shake the oral liquid well before each use. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Keep using this medicine for the full treatment time, even if you or your child feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the tablets in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the oral liquid in the refrigerator. Throw away any unused medicine after 14 days.

Precautions While Using This Medicine:

If your symptoms or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Cefpodoxime may cause diarrhea, and in some cases it can be severe. Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Before you or your child have any medical tests, tell the medical doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
loose stools
Less common
Change in the color, amount, or odor of vaginal discharge
Abdominal or stomach cramps or tenderness
black, tarry stools
bladder pain
bleeding gums
bloating or swelling of the face, arms, hands, lower legs, or feet
bloody nose
bloody or cloudy urine
blurred vision
burning while urinating
chest pain
collection of blood under the skin
continuing ringing or buzzing or other unexplained noise in the ears
cough or hoarseness
cough producing mucus
dark urine
decreased urination
decreased urine output
deep, dark purple bruise
diarrhea, watery and severe, which may also be bloody
difficult or labored breathing
difficult, burning, or painful urination
difficulty with breathing or troubled breathing
dilated neck veins
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
dry mouth
extreme fatigue
fast, irregular, pounding, or racing heartbeat or pulse
feeling of warmth or heat
fever or chills
flushing or redness of the skin, especially on the face and neck
frequent urge to urinate
general body swelling
hearing loss
heavier menstrual periods
increase in heart rate
increased thirst
increased urge to urinate during the night
increased weight
irregular breathing
irregular heartbeat
itching of the vagina or genital area
itching, pain, redness, or swelling
loss of appetite
lower back or side pain
nausea or vomiting
noisy breathing
pain during sexual intercourse
pain or swelling of the treated skin
pain or tenderness around the eyes and cheekbones
pain, warmth, or burning in the fingers, toes, and legs
pale skin
pinpoint red spots on the skin
pounding in the ears
problems with vision or hearing
rapid breathing
rapid weight gain
runny nose
shortness of breath or troubled breathing
skin rash
slow or fast heartbeat
sore throat
sores, ulcers, or white spots on the lips or in the mouth
stuffy or runny nose
sunken eyes
swelling of the face, fingers, feet, or lower legs
swelling or puffiness of the face
swollen glands
thick, white vaginal discharge with no odor or with a mild odor
tightness of the chest or wheezing
tingling of the hands or feet
troubled breathing
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
waking to urinate at night
weight gain
wrinkled skin
yellowing of the eyes or skin
Incidence not known
Abdominal or stomach pain
blistering, peeling, or loosening of the skin
bloody, black, or tarry stools
clay-colored stools
feeling of discomfort
fever with or without chills
general feeling of tiredness or weakness
high fever
inflammation of the joints
irritation or inflammation of the eyelid
joint or muscle pain
muscle aches
rectal bleeding
red skin lesions, often with a purple center
red, irritated eyes
sudden decrease in the amount of urine
swollen lymph glands
swollen or painful glands
unpleasant breath odor
vomiting of blood

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Accumulation of pus
acid or sour stomach
ankle, knee, or great toe joint pain
bad, unusual, or unpleasant (after) taste
blemishes on the skin
bloated or full feeling
burning feeling in the chest or stomach
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
change in taste
cracks in the skin
decreased appetite
difficulty with moving
dry skin
excess air or gas in the stomach or intestines
fear or nervousness
feeling of constant movement of self or surroundings
frequent urge to defecate
general feeling of discomfort or illness
hair loss
headache, severe and throbbing
hives or welts
increase in body movements
increased sweating
increased thirst
irritation or soreness of the mouth
joint stiffness or swelling
lack or loss of strength
loss of heat from the body
lower back or side pain
muscle aching or cramping
muscle pains or stiffness
passing of gas
peeling of the skin
poor concentration
pressure in the stomach
red, sore eyes
red, swollen skin
redness of the skin
scaly skin
seeing, hearing, or feeling things that are not there
sensation of spinning
sleepiness or unusual drowsiness
sore mouth or tongue
soreness or redness around the fingernails and toenails
stomach discomfort, upset, or pain
stomach upset
straining while passing stool
swelling of the abdominal or stomach area
swelling or inflammation of the mouth
swollen, red, or tender area of infection
trouble with sleeping
unable to sleep
white patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Last Updated: 9/15/2016

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