Health Guide
Drug Guide

Cisplatin (Intravenous route)

Pronunciation:

sis-PLA-tin

Brand Names:

Dosage Forms:

Warnings:

Intravenous route(Powder for Solution)

Administer under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Cumulative renal toxicity associated with cisplatin is severe and other major dose-related toxicities include myelosuppression, nausea, and vomiting. Ototoxicity, which may be more pronounced in children, is significant. Anaphylactic-like reactions to cisplatin such as facial edema, bronchoconstriction, tachycardia, and hypotension have been reported and may occur within minutes of cisplatin administration. Exercise caution to prevent inadvertent cisplatin overdose as doses greater than 100 mg/m(2)/cycle once every 3 to 4 weeks are rarely used. Avoid inadvertent cisplatin overdose due to confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle .

Classifications:

Therapeutic

Antineoplastic Agent

Pharmacologic

Platinum Coordination Complex

Uses of This Medicine:

Cisplatin belongs to the group of medicines known as alkylating agents. It is used to treat cancer of the bladder, ovaries, and testicles. It may also be used to treat other kinds of cancer, as determined by your doctor.

Cisplatin interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by cisplatin, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cisplatin, you and your doctor should talk about the good this medicine will do as well as the risks of using it.

Cisplatin is to be administered only by or under the immediate supervision of your doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, cisplatin is used in certain patients with the following medical conditions:

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children

Hearing problems and loss of balance are more likely to occur in children, who are usually more sensitive to the effects of cisplatin.

Older adults

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of cisplatin in the elderly with use in other age groups.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast-feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Other interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper Use of This Medicine:

This medicine is sometimes given together with certain other medicines. If you are using a combination of medicines, it is important that you receive each one at the proper time. If you are taking some of these medicines by mouth, ask your health care professional to help you plan a way to take them at the right times.

While you are receiving this medicine, your doctor may want you to drink extra fluids so that you will pass more urine. This will help prevent kidney problems and keep your kidneys working well.

This medicine usually causes nausea and vomiting that may be severe. However, it is very important that you continue to receive the medicine, even if you begin to feel ill. Ask your health care professional for ways to lessen these effects, especially if they are severe.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Precautions While Using This Medicine:

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

While you are being treated with cisplatin, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Cisplatin may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine within the last several months. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

Cisplatin can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

If cisplatin accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Tell the doctor or nurse right away if you notice redness, pain, or swelling at the place of injection.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way cancer medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur:

Less common
Black, tarry stools
blood in urine or stools
cough or hoarseness accompanied by fever or chills
dizziness or faintness (during or shortly after a dose)
fast heartbeat (during or shortly after a dose)
fever or chills
lower back or side pain accompanied by fever or chills
painful or difficult urination accompanied by fever or chills
pain or redness at place of injection
pinpoint red spots on skin
swelling of face (during or shortly after a dose)
unusual bleeding or bruising
wheezing (during or shortly after a dose)

Check with your doctor as soon as possible if any of the following side effects occur:

More common
Joint pain
loss of balance
ringing in ears
swelling of feet or lower legs
trouble in hearing
unusual tiredness or weakness
Less common
Convulsions (seizures)
loss of reflexes
loss of taste
numbness or tingling in fingers or toes
trouble in walking
Rare
Agitation or confusion
blurred vision
change in ability to see colors (especially blue or yellow)
muscle cramps
sores in mouth and on lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Nausea and vomiting (severe)
Less common
Loss of appetite

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
decrease in urination
fever or chills
loss of balance
loss of reflexes
loss of taste
lower back or side pain
numbness or tingling in fingers or toes
painful or difficult urination
pinpoint red spots on skin
ringing in ears
swelling of feet or lower legs
trouble in hearing
trouble in walking
unusual bleeding or bruising

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 10/12/2016

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