Health Guide
Drug Guide

Brinzolamide (Ophthalmic route)

Pronunciation:

brin-ZOE-la-mide

Brand Names:

Dosage Forms:

Classifications:

Therapeutic

Antiglaucoma

Pharmacologic

Carbonic Anhydrase Inhibitor

Uses of This Medicine:

Brinzolamide ophthalmic (eye) drops is used to treat increased pressure in the eye caused by open-angle glaucoma or a condition called ocular hypertension. Both eye conditions are caused by high pressure in your eye and can lead to pain from pressure in your eye and then can eventually harm your vision. This medicine can help you keep your sight by reducing the pressure in your eye and stopping eye pain.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children

Appropriate studies have not been performed on the relationship of age to the effects of brinzolamide eye drops in the pediatric population. Safety and efficacy have not been established.

Older adults

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of brinzolamide eye drops in the elderly.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Other interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper Use of This Medicine:

Your eye doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.

If you normally wear soft contact lenses, remove them before you use brinzolamide eye drops. Wait at least 15 minutes before putting the contact lenses back in.

To use the eye drops:

If your doctor ordered two different eye drops to be used together, wait at least 10 minutes between the times you apply the medicines. This will help to keep the second medicine from “washing out” the first one.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

You may also keep the medicine in the refrigerator. Also, keep the bottle upright when you are not using it.

Precautions While Using This Medicine:

It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly and is not causing unwanted effects.

If itching, redness, swelling, or other signs of eye or eyelid irritation occur, check with your doctor. These signs may mean that you are allergic to brinzolamide.

Serious allergic reactions may occur while using this medicine. Stop using this medicine and check with your doctor right away if you have any of the following symptoms: black, tarry stools; blistering, peeling, or loosening of the skin; chills; dark urine; joint or muscle pain; rash; red skin lesions, often with a purple center; sores, ulcers, or white spots in the mouth or on the lips; unusual bleeding or bruising; unusual tiredness or weakness; or yellow eyes or skin.

If you hurt your eye, develop an eye infection, or need to have an eye surgery, talk with your doctor right away. Your doctor may want you to use a new bottle of the eye drops to help prevent an eye infection or keep an infection from getting worse.

This medicine may cause some people to have blurred vision for a short time. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you cannot see properly. Also, since blurred vision may be a sign of a side effect that needs medical attention, check with your doctor if it continues.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
Blurred vision
Less common
Discharge from the eye
dry eyes
redness, soreness, irritation, or pain of the eye or eyelid
skin rash
Rare
Chest pain
cough
crusting in the corner of the eye
difficulty with swallowing
dizziness
double vision
excessive muscle tone
eye redness, irritation, or pain
fast heartbeat
hives
itching, swelling, or other signs of eye or eyelid irritation
kidney pain
muscle stiffness
muscle tension or tightness
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
seeing double
shortness of breath
sore throat
tightness in the chest
unusual tiredness or weakness
wheezing
Incidence not known
Abdominal or stomach pain
blistering, peeling, or loosening of the skin
chills
clay-colored stools
dark urine
diarrhea
fever with or without chills
general feeling of tiredness or weakness
headache
hoarseness
joint or muscle pain
loss of appetite
lower back or side pain
nausea
painful or difficult urination
red or irritated eyes
red skin lesions, often with a purple center
sores, ulcers, or white spots on the lips or in the mouth
swollen or painful glands
unpleasant breath odor
unusual bleeding or bruising
vomiting of blood
yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose
Confusion
irregular heartbeat
muscle cramps or pain
numbness, tingling, pain, or weakness in the hands or feet
seizures
trembling
weakness and heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Bitter, sour, or other unusual taste
Less common
Burning, stinging, or discomfort when medicine is applied
dry eyes
feeling of something in the eye
runny nose
sneezing
stuffy nose
Rare
Acid or sour stomach
belching
body aches or pain
congestion
difficult or labored breathing
dry mouth
hair loss
heartburn
hives or welts
indigestion
stomach discomfort, upset, or pain
tender, swollen glands in the neck
thinning of the hair
voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 10/12/2016

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