Health Guide
Drug Guide

Anagrelide (Oral route)

Pronunciation:

an-AG-re-lide

Brand Names:

Dosage Forms:

Classifications:

Therapeutic

Platelet Reducing Agent

Uses of This Medicine:

Anagrelide is used to decrease the risk of blood clots in patients who have thrombocythemia (too many platelets in the blood). It works to decrease production of platelets in the body.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of anagrelide in children.

Older adults

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anagrelide in the elderly.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Other interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper Use of This Medicine:

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects.

You may take this medicine with or without food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using This Medicine:

It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood tests are needed to check for unwanted effects. You will also need to have an ECG test (electrocardiogram) to check your heart rhythm.

This medicine may cause unwanted effects on the heart. Check with your doctor right away if you or your child have chest pain, tightness, or discomfort, decreased urine output, dilated neck veins, extreme fatigue, a fast, pounding, or uneven heartbeat or pulse, pain or discomfort in the arms, jaw, back or neck, nausea or vomiting, sweating, swelling of the face, fingers, feet, or lower legs, trouble breathing, or weight gain. These could be symptoms of a serious heart problem.

This medicine may also increase your risk of bleeding. Check with your doctor immediately if you or your child notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Check with your doctor right away if you or your child have breathing problems, a cough, a fever, a fast heartbeat, or shortness of breath. These could be symptoms of a serious lung problem.

Do not stop using this medicine suddenly without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely. To do so will cause the platelet level in your blood to increase quickly.

Do not take aspirin or aspirin-containing products since they may also affect your platelets. Do not take any other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
Bloating or swelling of the face, arms, hands, lower legs, or feet
body aches or pain
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain
congestion
cough
difficult or labored breathing
dryness or soreness of the throat
fast, irregular, pounding, or racing heartbeat or pulse
fever
hoarseness
rapid weight gain
runny nose
tender, swollen glands in the neck
tightness in the chest
trouble with swallowing
voice changes
Less common
Anxiety
blurred vision
burning while urinating
chills
cold sweats
confusion
decreased urine output
dehydration
difficult or painful urination
dilated neck veins
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
extreme fatigue
general feeling of discomfort or illness
headache
irregular breathing
joint pain
large, flat, blue, or purplish patches in the skin
loss of appetite
muscle aches and pains
nausea or vomiting
noisy breathing
pale skin
redness of the face, neck, arms, and occasionally, upper chest
severe pain or pressure in the chest or the jaw, neck, back, or arms
sudden severe headache or weakness
swollen, painful, or tender lymph glands in the neck, armpit, or groin
trouble sleeping
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness
vomiting of blood or material that looks like coffee grounds
weight gain
Incidence not known
Abdominal or stomach pain or tenderness
clay colored stools
dark urine
decreased appetite
dry cough
general feeling of tiredness or weakness
rapid breathing
skin rash or itching
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Acid or sour stomach
back pain
belching
diarrhea
excess air or gas in the stomach or intestines
full feeling
general feeling of discomfort or illness
heartburn
hives or welts
indigestion
lack or loss of strength
pain
passing gas
stomach discomfort, upset, or pain
Less common
Burning feeling in the chest or stomach
change in vision
confusion
constipation
continuing ringing or buzzing or other unexplained noise in the ears
depression
difficulty with moving
double vision
hair loss or thinning of the hair
hearing loss
impaired vision
increased sensitivity of the skin to sunlight
leg cramps
loss of memory
muscle pain or stiffness
problems with memory
redness or other discoloration of the skin
seeing double
severe sunburn
sleepiness or unusual drowsiness
stuffy nose
swelling or inflammation of the mouth
swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 10/12/2016

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