Health Guide
Drug Guide


What is it?

Progesterone is a hormone that is found naturally in the human body. It is taken for hormone replacement in women during menopause, female infertility (difficulty getting pregnant), and menstrual (monthly period) problems.

Other names for progesterone include: micronized progesterone and natural progesterone.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you


Talk with your caregiver about how much progesterone you should take. The amount depends on the strength of the medicine and the reason you are taking progesterone. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Drug and Food Interactions:

Do not take progesterone without talking to your doctor first if you are taking:


Side Effects:

Call your doctor right away if you have any of these side effects:

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.


1. Fitzpatrick LA & Good A: Micronized progesterone: clinical indications and comparison with current treatment. Fertil Steril 1999; 72(3):389-397.

2. Balasch J, Fabregues F, Ordi J et al: Further data favoring the hypothesis of the uterine first-pass effect of vaginally administered micronized progesterone. Gynecol Endocrinol 1996; 10:421-426.

3. Friedler S, Raziel A, Schachter M et al: Luteal support with micronized progesterone following in-vitro fertilization using a down-regulation protocol with gonadotrophin-releasing hormone agonist: a comparative study between vaginal and oral administration. Human Reproduction 1999; 14(8):1944-1948.

4. Leonetti HB, Longo S, Anasti JN: Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstet Gynecol 1999; 94(2): 225-8.

5. Product Information: Prometrium®, progesterone. Solvay Pharmaceuticals, Inc., Marietta, GA, 1999.

6. Freeman EW, Rickels K, Sondheimer SJ et al: A double-blind trial of oral progesterone, alprazolam, and placebo in treatment of severe premenstrual syndrome. JAMA 1995; 274(1):51-57.

7. Zava DT, Dollbaum CM & Blen M: Estrogen and progestin bioactivity of foods, herbs, and spices. PSEBM 1998; 217(3):369-378.

8. Product Information: Adriamycin RDF(R), doxorubicin hydrochloride. Pharmacia & Upjohn Company, Kalamazoo, MI, 1999.

9. Product Information: Prometrium(R), progesterone. Solvay Pharmaceuticals, Inc., Marietta, GA, 2004.

Last Updated: 9/15/2016

Thomson Micromedex. All rights reserved.

Thomson & A.D.A.M