Health Guide
Drug Guide


What is it?

SAMe is an abbreviation for S-Adensyl Methionine, which is an essential amino acid that is used as a supplement for liver support, osteoarthritis, depression, fibromyalgia, schizophrenia, migraine headaches, and to increase bile flow.

Other names for SAMe include: S-Adensyl Methionine, L-Methionine, Adomet, and Ademethionine.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you


Talk with your caregiver about how much SAMe you should take. The amount depends on the strength of the medicine and the reason you are taking SAMe. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Drug and Food Interactions:

Do not take SAMe without talking to your doctor first if you are taking:


Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.


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8. Konig B: A long-term (two years) clinical trail with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83(suppl5A):89-94.

9. Padova C, Tritapepe R, Di Padova F et al: S-adenosl-L-methionine antagonizes oral contaceptive-induced bile cholesterol supersaturation in health women: Preliminary report of a controlled ramdomized trial. AM J Gastroentrol 1984;79:941-944.

10. Frezza M et al: Reversal of intrahepatic cholestasis of pregnancy in women after high dose S-adenosyl-L-methionie (SAMe) administration. Hepatology 1984;4:274-278.

11. Iruela LM, Minguez L, Merino J et al: Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psychiatry 1993; 150(3):522.

Last Updated: 9/15/2016

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