Health Guide
Drug Guide


What is it?

Coumarin can be found in many plants including dong quai, red clover, sweet clover, and tonka bean. It is used mainly in the treatment of cancer and can also be used as a blood thinner.

Other names for coumarin include: 1,2-benzopyrone, tonka bean camphor, cumarin, kumaryna.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you


Talk with your caregiver about how much coumarin you should take. The amount depends on the strength of the medicine and the reason you are taking Coumarin. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Drug and Food Interactions: Coumarin may interact with other medicines you may be taking. Talk with your doctor, pharmacist, or nurse before taking coumarin with any other medicine.


Side Effects:

Call your doctor right away if you have any of these side effects:

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.


1. Berkarda B, Bouffard-Eyuboglu H & Derman U: The effect of coumarin derivatives on the immunological system of man. Agents Actions 1983;13:50-52.

2. Dexeus FH, Logothetis CJ, Sella A et al: Phase II study of coumarin and cimetidine in patients with metastatic renal carcinoma. J Clin Oncol 1992; 8:325-330.

3. Marshall ME, Butler K & Fried A: Phase I evaluation of coumarin (1,2-benzopryne) and cimetidine in patients with advanced malignancies. Mol Biother 1991; 3:170-178.

4. Marshall ME, Riley LK, Rhoades J et al: Effects of coumarin (1,2-benzopryne) and cimetidine on peripheral blood lymphocytes, natural killer cells, and monocytes in patients with advanced malignancies. J Biol Resp Mod 1989; 8(1):62-69.

5. Marshall ME, Mendelsohn L, Butler K et al: Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopryne) and cimetidine: a pilot study. J Clin Oncol 1987; 5(6):862-866.

6. Mohler JL, Gomella LG, Crawford D et al: Phase II evaluation of coumarin (1,2-Benzpyrone) in metastatic prostatic carcinoma. Prostate 1992; 20:123-131.

7. Product Information: Coumadin(R), warfarin. Bristol Myers Squibb, New York, NY, 2006.

Last Updated: 9/15/2016

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