Health Guide
Drug Guide

Citrus bioflavonoids

What is it?

Citrus Bioflavonoids are a class of flavonoids that include rutin, hesperidin, naringin, quercitin, and a standardized mixture of rutinosides known as hydroxyethylrutosides (HER). They are used for the treatment of capillary fragility (easy bruising) and venous insufficiency (varicose veins, hemorrhoids, diabetic vascular disease, and diabetic retinopathy).

Other names for Citrus Bioflavonoids include: Rutin, Hesperidin, Naringin, Quercitin, and HER.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you


Talk with your caregiver about how much Citrus Bioflavonoids you should take. The amount depends on the strength of the medicine and the reason you are taking Citrus Bioflavonoids. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.


Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

Other Side Effects:

This medicine may cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.


1. Murray, MT: Encyclopedia of Nutritional Supplements. Prima Publishing, Rocklin, CA; 1996.

2. Wadsworth AN & Faulds D: Hydroxyethylrutosides: A review of its pharmacology and therapeutic efficacy in venous insufficiency and related disorders. Drugs 1992;44:1013,1032.

3. Poynard T & Valterio C: Meta-analysis of hydrozyethylrutodides in the treatment of chronic venous insuffiiciency. Vasa 1994; 23:244-250.

4. Boisseau ME Taccoen A, Garreau C et al: Fibrinolysis and hemorrheology in chronic venous insufficiency: A double blind study of troxerutin efficacy. J Cardiovasc Surg 1995;36:369-374.

5. Neumann HA and van den Broek MJ: A comparative clinical trial of graduated compression stockings and O-(beta-hydroxyethyl)-rutosides (HR) in the treatment of patients with chronic venous insufficiency. Z Lymphol 1995;19:8-11.

6. Renton S, Leon M, Belcaro G et al: The effect of hydroxyethylrotodides on capillary filtration in moderate venous hypertension: A double blind study. Int Angiol 1994;13:259-262.

7. MacLennan WJ, Wilson J, Rattenhuber V et al: Hydroxyethylrutosides in elderly patients with chronic venous insufficiency: Its efficacy and tolerability. Gerontology 1994;40:45-52.

8. Bergstein NAM: Clinical study on the efficacy of O-(beta-hydroxyethyl)-rutodside (HR) in varicosis of pregnancy. J Int Med Res 1992; 3:189-193.

Last Updated: 9/15/2016

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