Minneapolis Heart Institute again selected to participate in Cardiovascular Cell Therapy Research Network
MINNEAPOLIS 04/09/2012--Minneapolis Heart Institute® at Abbott Northwestern Hospital has been selected by the Cardiovascular Cell Therapy Research Network as one of its seven U.S. centers of excellence. The network will receive $63 million from the National Institutes of Health's National Heart, Lung and Blood Institute over the next seven years to help achieve its mission of driving public health advances in cardiovascular cell therapy for the treatment of cardiovascular diseases.
MHI was integral to the success of the first CCTRN initiative—a series of clinical studies that took place over five years involving five sites using bone marrow stem cells in patients with heart disease, and in which nearly 50 percent of the patients were enrolled in Minnesota. As principal investigator, Timothy D. Henry, MD, director of research at the Minneapolis Heart Institute Foundation, will be responsible for a network of Minnesota hospitals including the Minneapolis Heart Institute® at Abbott Northwestern Hospital in Minneapolis, the University of Minnesota in Minneapolis, Mayo Clinic in Rochester, United Hospital in St. Paul, Mercy Hospital in Coon Rapids and Hennepin County Medical Center in Minneapolis.
This extension of CCTRN already has three trials planned, including
- An allogeneic mesenchymal cell for patients with advanced heart function requiring left ventricular assist device;
- An enhanced autologous bone marrow cell for patients with claudication (leg pain while walking); and
- A combination of a bone marrow cell and a novel cardiac derived cell for patients with heart failure.
"These trials will play a key role in identifying the benefits of cell therapy in patients with cardiovascular disease. The Minneapolis Heart Institute at Abbott Northwestern Hospital has been a leader in cardiovascular cell therapy research with more than 300 patients treated for a variety of conditions including acute heart attack, heart failure, ischemic heart disease and peripheral arterial disease," Henry said. "The first CCTRN was highly successful in achieving the NIH's goal of promoting clinical research and has led to the expansion of the network to seven clinical centers for seven years.
Henry noted the remarkable progress in cell therapy over the past several years. Currently, there are several large Phase 3 trials, which if proven efficacious, will lead to cell therapy added to the armamentarium for treating patients with challenging cardiovascular diseases. The CCTRN in particular is critical to provide key insights into the preferred cell, and method of delivery to increase the chance of success.
The CCTRN was created to support the collaboration of physicians, researchers and support staff with expertise in innovative stem cell therapies and experience in leading clinical trials that evaluate leading edge treatments for heart disease. The CCTRN also includes the University of Miami, the University of Florida, Stanford University, Texas Heart Institute, Indiana University and University of Louisville.
Cardiovascular disease remains the leading cause of death in the United States, claiming nearly 900,000 lives each year and more lives than the next five leading causes of death combined. One in three Americans suffer from some form of cardiovascular disease and associated costs are estimated at $432 billion in 2007.
Minneapolis Heart Institute® at Abbott Northwestern Hospital
Minneapolis Heart Institute® at Abbott Northwestern Hospital is part of Allina Hospitals & Clinics, a not-for-profit system of hospitals, clinics and other health care services providing care throughout Minnesota and western Wisconsin. The Institute is recognized internationally as one of the world’s leading providers of heart and vascular care. The Institute’s programs address the full range of heart and vascular health needs: prevention, diagnosis, treatment and rehabilitation.
Minneapolis Heart Institute Foundation
The Minneapolis Heart Institute Foundation is dedicated to creating a world without heart disease through groundbreaking clinical research and innovative education programs. MHIF's mission is to promote and improve cardiovascular health, quality of life and longevity for all.# # #