Ibrutinib (By mouth)
Treats mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL).
ImbruvicaThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. Do not use it if you had an allergic reaction to ibrutinib, or if you are pregnant.
How to Use This Medicine:
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Take your medicine as directed. Take this medicine at the same time each day.
- Swallow the capsule whole with a glass of water. Do not open, crush, break, or chew it.
- Drink plenty of water each day to help prevent dehydration.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some foods and medicines can affect how ibrutinib works. Tell your doctor if you are using the following:
- St John's wort, aprepitant, carbamazepine, crizotinib, diltiazem, imatinib, nefazodone, phenytoin, rifampin, or verapamil
- Medicine to treat HIV (atazanavir, darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir), medicine to treat hepatitis (boceprevir, telapravir), an antibiotic (such as clarithromycin, erythromycin, telithromycin), medicine to treat a fungus infection (fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole), antiplatelet medicine (such as aspirin), or a blood thinner (such as warfarin)
- Do not eat grapefruit or Seville oranges, or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, or a history of heart rhythm problems.
- This medicine may cause the following problems:
- Heart rhythm problems (atrial fibrillation, atrial flutter)
- Higher risk of new cancers, including skin cancer
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Bloody stools, or vomiting of blood or material that looks like coffee grounds
- Decrease in how much or how often you urinate, lower back or side pain
- Fast or uneven heartbeat, lightheadedness, dizziness, fainting
- Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
- Trouble breathing
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Diarrhea, constipation, nausea, vomiting, loss of appetite, or stomach pain
- Muscle or joint pain
- Rapid weight gain, swelling in your hands, ankles, or feet
- Sores or white patches on your lips, mouth, or throat
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 11/4/2014
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