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Atorvastatin/ezetimibe (By mouth)

Atorvastatin Calcium (a-tor-va-STAT-in KAL-see-um), Ezetimibe (ez-ET-i-mide)

Lowers high cholesterol and triglyceride levels in the blood. This medicine contains an HMG-CoA inhibitor (statin).

Brand Name(s):

Liptruzet

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to atorvastatin or ezetimibe. Do not use this medicine if you are pregnant or breastfeeding, or if you have active liver disease.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Swallow the tablet whole. Do not crush, break, chew, or dissolve it.
  • Carefully follow your doctor's instructions about diet and exercise. This medicine is part of a complete plan for lowering cholesterol and triglycerides in your blood.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Keep your medicine in the foil pouch until you are ready to use it. After you open the foil pouch, store it in a dry place and protect from moisture and light. After you remove a tablet, slide the blister card back into its plastic case.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.Throw away any unused tablets 30 days after you open the foil pouch.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using cyclosporine (Gengraf®, Neoral®, Sandimmune®), gemfibrozil (Lopid®), telaprevir (Incivek®), or medicine to treat HIV/AIDS (such as tipranavir/ritonavir, Aptivus®, Norvir®). You should not use these medicines together with Liptruzet? unless your doctor tells you to.
  • Make sure your doctor knows if you are also using colchicine (Colcrys®), niacin, other medicine to lower cholesterol (such as fenofibrate, fenofibric acid, Tricor®), medicine to treat HIV/AIDS (such as darunavir, efavirenz, fosamprenavir, lopinavir, nelfinavir, ritonavir, saquinavir, Kaletra®, Lexiva®, Prezista®, Reyataz®), medicine to treat hepatitis C (such as boceprevir, Victrelis®), or medicine to treat an infection (such as clarithromycin, erythromycin, itraconazole, ketoconazole, rifampin, Diflucan®, Nizoral®, Rifadin®, Rimactane®).
  • Tell your doctor if you also use cimetidine (Tagamet®), digoxin (Lanoxin®), spironolactone (Aldactone®), birth control pills, or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
  • If you are taking other medicine to lower cholesterol (such as cholestyramine, colesevelam, colestipol, Questran®, Welchol®), tell your doctor and pharmacist. You might need to take Liptruzet? 2 hours before or 4 hours after you take these other medicines.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
  • Do not drink more than 1.2 liters of grapefruit juice per day.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you have kidney disease, diabetes, low blood pressure, seizures, thyroid problems, or muscle pain or weakness. Tell your doctor if you have a history of liver disease or if you drink alcohol regularly.
  • Rarely, this medicine can cause serious side effects that involves muscles and kidneys. Stop taking this medicine and call your doctor if you have severe muscle pain, weakness, or tenderness for no reason, especially if you also have a fever and feel weak and tired. Also tell your doctor if you have a change in how much or how often you urinate or your urine turns a dark color.
  • Make sure any doctor or dentist who treats you knows that you use this medicine. You may need to stop using this medicine if you have major surgery, a major injury, or other serious health problems.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fever
  • Unexplained muscle pain, tenderness, or weakness
  • Unusual tiredness

If you notice these less serious side effects, talk with your doctor:

  • Stomach pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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