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Ado-trastuzumab emtansine (Injection)

Ado-Trastuzumab Emtansine (AY-doh tras-TOOZ-oo-mab em-TAN-seen)

Treats metastatic breast cancer.

Brand Name(s):

Kadcyla

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to trastuzumab or ado-trastuzumab, or if you are pregnant.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • This medicine is usually given once every 3 weeks.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using medicine to treat HIV/AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Norvir®, Reyataz®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, telithromycin, voriconazole, Nizoral®), or medicine to treat depression (such as nefazodone, Serzone®).

Warnings While Using This Medicine:

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for 6 months after the last dose. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have liver disease, heart failure, lung disease, or bleeding problems.
  • This medicine may cause a serious infusion reaction. Tell your doctor or nurse right away if you have warmth or redness in your face or upper body, fever, chills, chest pain, lightheadedness, dizziness, fainting, headache, trouble breathing, or weakness while you are receiving the medicine or after the infusion.
  • Make sure your doctor knows if you have used trastuzumab (Herceptin®) before.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Your treatment may need to be changed or stopped if you have any severe side effect caused by this medicine.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, cough
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, upper stomach pain, yellow skin or eyes
  • Fever, chills, cough, sore throat, runny or stuffy nose, body aches
  • Infusion reaction: Fever, chills, trouble breathing, lightheadedness, fast heartbeat
  • Lightheadedness, dizziness, fainting
  • Numbness, tingling, or burning pain in hands, arms, legs, or feet
  • Pain, redness, itching, burning, swelling, or a lump under your skin where the needle is placed
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, constipation
  • Headache
  • Muscle, joint, or bone pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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