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Alogliptin/metformin (By mouth)

Alogliptin Benzoate (al-oh-GLIP-tin BEN-zoe-ate), Metformin Hydrochloride (met-FOR-min hye-droe-KLOR-ide)

Treats type 2 diabetes. Used together with proper diet and exercise to help control high blood sugar.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to alogliptin or metformin, or if you have kidney disease or metabolic acidosis (including diabetic ketoacidosis).

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk.
  • Swallow the tablet whole. Do not crush, break, or chew it.
  • Carefully follow your doctor's instructions about any special diet or exercise program. Test your blood sugar regularly.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using insulin or other medicine to treat your diabetes such as glimepiride, glipizide, glyburide, pioglitazone, Actos®, or Amaryl®.
  • Make sure your doctor knows if you are also using acetazolamide (Diamox®), cimetidine (Tagamet®), dichlorphenamide (Daranide®), digoxin (Lanoxin®), isoniazid (Nydrazid®), morphine, niacin (vitamin B3), phenytoin (Dilantin®), procainamide (Procanbid®), quinidine (Quinidex®), quinine (Qualaquin®), ranitidine (Zantac®), topiramate (Topamax®), trimethoprim (Proloprim®, Trimpex®), vancomycin (Vancocin®), or zonisamide (Zonegram®).
  • Tell your doctor if you are also using blood pressure medicine (such as amlodipine, atenolol, diltiazem, metoprolol, nifedipine, propranolol, verapamil, Bystolic®, Caduet®, Lotrel®, Tenormin®), a diuretic (water pill, such as amiloride, furosemide, hydrochlorothiazide, torsemide, triamterene, Lasix®), a phenothiazine medicine (such as promethazine, Phenergan®, Thorazine®), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone), a thyroid replacement (such as levothyroxine, liothyronine, Cytomel®, Synthroid®), estrogen hormones (Premarin®), or birth control pills.
  • Do not drink excessive amounts of alcohol while taking this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, congestive heart failure, gallstones, heart disease, anemia, vitamin B12 deficiency, or a history of alcohol abuse or pancreas problems.
  • Do not use this medicine to treat type 1 diabetes.
  • Rarely, this medicine may cause a serious condition called lactic acidosis. Call your doctor right away if you feel unusually tired or weak, have muscle pain, trouble breathing, or an upset stomach. Lactic acidosis is more likely to happen if you have kidney or liver problems, a severe infection (sepsis), or hypoxemia (low oxygen levels in your blood) or if you are dehydrated. Tell your doctor if you get sick and have a fever, vomiting, or diarrhea, because these could cause dehydration. Drink plenty of fluids, especially if you exercise or are active in hot weather.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an X-ray or a CT scan.
  • You may develop low blood sugar while you are taking this medicine. You may feel weak, drowsy, confused, anxious, or very hungry. You may have trouble seeing or have a headache that won't go away. Tell your doctor if this happens. Low blood sugar may be caused by exercising more than normal or waiting too long to eat.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Change in how much or how often you urinate
  • Dark-colored urine or pale stools, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fast, slow, or pounding heartbeat
  • Lightheadedness or fainting
  • Rapid breathing, trouble breathing, nausea, and vomiting
  • Shaking, trembling, sweating, hunger, confusion
  • Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness

If you notice these less serious side effects, talk with your doctor:

  • Cough, stuffy or runny nose, sore throat
  • Diarrhea
  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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