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Pomalidomide (By mouth)

Pomalidomide (poe-ma-LID-oh-mide)

Treats multiple myeloma. This medicine is an antineoplastic.

Brand Name(s):

Pomalyst

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine can cause serious or life-threatening birth defects in unborn babies. Do not use this medicine if you are pregnant. Do not use this medicine if you have had an allergic reaction to pomalidomide.

How to Use This Medicine:

Capsule

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Take your medicine as directed.
  • Take this medicine with water at the same time each day.
  • Take this medicine on an empty stomach, at least 2 hours before or 2 hours after a meal.
  • Do not break, chew, or open the capsules. If you accidentally open the capsule or touch the medicine inside, wash your skin with soap and water right away.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • If you miss a dose of this medicine and it is less than 12 hours since your regular time, take it as soon as you can and take your next dose at the normal time. If you miss a dose and it is more than 12 hours since your regular time, skip the missed dose and take your next dose at the normal time. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use ketoconazole (Nizoral®) or rifampin (Rifadin®, Rimactane®).
  • Avoid cigarette smoking while you use this medicine.

Warnings While Using This Medicine:

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant.
  • Make sure your doctor knows if you are breastfeeding or if you have kidney disease, liver disease, blood clotting problems, or nerve problems.
  • Pregnancy tests are required before and during therapy. Women should use 2 forms of effective birth control together to avoid pregnancy. Begin using birth control 4 weeks before you start therapy. Continue the birth control during therapy, even if the dose is stopped for a short time, and for at least 4 weeks after your last dose. Talk to your doctor about the most effective forms of birth control for you and your partner.
  • Men must protect their female partner from getting pregnant. Use a latex or synthetic condom every time you have sex, even if you have had a vasectomy. You must use a condom during therapy, even if the dose is stopped for a short time, and for up to 28 days after your last dose. Do not donate sperm while you take this medicine.
  • Do not donate blood during therapy and for at least 1 month after your last dose.
  • This medicine may increase your risk for blood clots. Tell your doctor right away if you have trouble breathing, chest pain, or swelling in your arm or leg.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • This medicine may cause nerve damage. Call your doctor if you have any numbness, tingling, burning, or pain in the hands or feet.
  • This medicine may cause you to feel dizzy or confused. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, coughing up blood
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Pain in your lower leg (calf), numbness or weakness in your arm, leg, or on one side of your body
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Sudden or severe headache, problems with vision, speech, or walking
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Back pain
  • Constipation, diarrhea, nausea
  • Decreased appetite
  • Dizziness or confusion
  • Rash
  • Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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