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Alogliptin/pioglitazone (By mouth)

Alogliptin Benzoate (al-oh-GLIP-tin BEN-zoe-ate), Pioglitazone Hydrochloride (pye-oh-GLI-ta-zone hye-droe-KLOR-ide)

Treats type 2 diabetes. Used together with proper diet and exercise to help control high blood sugar.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to alogliptin or pioglitazone, or if you have severe heart failure or active bladder cancer.

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Swallow the tablet whole. Do not crush, break, or chew it.
  • Carefully follow your doctor's instructions about any special diet or exercise program. Test your blood sugar regularly.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using insulin or other medicine to treat your diabetes (such as glimepiride, glipizide, glyburide, metformin, Amaryl®). Tell your doctor if you are using gemfibrozil (Lopid®) or rifampin (Rifadin®, Rimactane®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding. Certain women may be at an increased risk for pregnancy while taking this medicine. If you had problems ovulating and had irregular periods in the past, this medicine may cause you to ovulate. This could increase your chance of becoming pregnant. Talk to your doctor about effective birth control while you are using this medicine.
  • Make sure your doctor knows if you have kidney disease, liver disease, congestive heart failure, edema (problems with fluid retention or swelling), macular edema (swelling of the back of the eye), fragile bones (especially women), gallstones, or a history of alcohol abuse or bladder cancer. Tell your doctor if you recently had a fever, infection, injury, or surgery.
  • Do not use this medicine to treat type 1 diabetes or diabetic ketoacidosis.
  • Check with your doctor right away if you have trouble breathing; your hands, ankles, or feet swell; or you suddenly gain weight for no reason. These may be symptoms of heart problems.
  • This medicine may increase the risk of broken bones in women. Ask your doctor about ways to keep your bones strong to help prevent fractures.
  • Using this medicine for a long time may increase your risk for bladder cancer. Tell your doctor right away if you have blood in the urine, need to urinate more often, feel pain when you urinate, or feel pain in the back or lower abdomen.
  • You may develop low blood sugar while you are taking this medicine. You may feel weak, drowsy, confused, anxious, or very hungry. You may have trouble seeing or have a headache that won't go away. Tell your doctor if this happens. Low blood sugar may be caused by exercising more than normal or waiting too long to eat.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Blurred vision or other changes in vision
  • Change in how much or how often you urinate, painful urination, lower back or side pain
  • Dark-colored urine or pale stools, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Pain or swelling in the arms or legs without an injury
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion
  • Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness
  • Trouble breathing, cold sweat, bluish-colored skin

If you notice these less serious side effects, talk with your doctor:

  • Cough, runny or stuffy nose, sneezing, or sore throat
  • Headache
  • Muscle pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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