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Alogliptin/pioglitazone (By mouth)

Alogliptin Benzoate (al-oh-GLIP-tin BEN-zoe-ate), Pioglitazone Hydrochloride (pye-oh-GLI-ta-zone hye-droe-KLOR-ide)

Treats type 2 diabetes.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to alogliptin or pioglitazone, or if you have severe heart failure or active bladder cancer.

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Swallow the tablet whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how alogliptin/pioglitazone works. Tell your doctor if you are using any of the following:
    • Gemfibrozil
    • Insulin or another diabetes medicine, such as glimepiride, glipizide, glyburide, metformin
    • Rifampin

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating and had irregular periods in the past, this medicine may cause you to ovulate. Talk to your doctor about effective birth control while you are taking this medicine.
  • Tell your doctor if you have kidney disease, liver disease, heart failure, edema (problems with fluid retention or swelling), macular edema (swelling of the back of the eye), fragile bones, gallstones, or a history of alcohol abuse or bladder cancer. Tell your doctor if you recently had a fever, infection, injury, or surgery, or if you have a scheduled surgery.
  • Do not use this medicine to treat type 1 diabetes or diabetic ketoacidosis.
  • This medicine may cause the following problems:
    • Heart problems
    • Increased risk for broken bones (in women)
    • Increased risk for bladder cancer if you use this medicine for a long time
    • Hypoglycemia (low blood sugar level), especially if you exercise more than normal or wait too long to eat
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Blurred vision or other changes in vision
  • Change in how much or how often you urinate, painful urination, lower back or side pain
  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
  • Pain in your arms or legs, muscle pain
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion
  • Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness
  • Trouble breathing, cold sweat, bluish skin

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 3/28/2016
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