Leuprolide/norethindrone (Injection, by mouth)
Treats pain caused by endometriosis.
Brand Name(s):There may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not receive this medicine if you have had an allergic reaction to leuprolide or norethindrone. You should not receive this medicine if you are pregnant, may become pregnant, are breastfeeding, or have any unusual uterine bleeding that has not been checked by your doctor. You should not receive this medicine if you have liver disease or tumors, blood clotting problems, heart attack, stroke, or a history of breast cancer or other hormone-sensitive cancer.
How to Use This Medicine:
- Lupaneta Pack® is a kit that contains 2 medicines that work together.
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
- A nurse or other health provider will give you this medicine.
- This is a long-acting medicine that is given once a month or once every 3 months, for up to 6 months of treatment.
- Take your medicine as directed. This medicine should be taken every day while you are being treated with the injection medicine, for up to 6 months.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
If a dose is missed:
- Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use medicine for seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Tegretol®) or steroid medicine (such as dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone, Medrol®).
- Tell your doctor if you drink alcohol on a regular basis, or if you smoke or use tobacco products.
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control that does not contains hormones.
- Make sure your doctor knows if you have kidney problems, epilepsy (seizures), migraine headaches, osteoporosis, vision problems, or a history of depression.
- Tell your doctor if you have asthma, allergies (especially drug allergies), high blood pressure, diabetes, heart disease, high cholesterol, or blood clotting problems.
- This medicine can decrease bone mineral density, which may lead to osteoporosis or weak bones. Talk with your doctor about how this risk will affect you.
- Endometriosis symptoms may get worse for a short time when you first start using this medicine. These symptoms should get better as your body gets used to the medicine.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Feeling depressed
- Sudden loss of vision, double vision, bulging eyes, migraine headache
- Sudden weight gain
- Swelling in your hands, arms, ankles, or feet
If you notice these less serious side effects, talk with your doctor:
- Headache, migraine
- Hot flashes, warmth or redness in your face, neck, arms, or upper chest
- Mood swings, feeling nervous or sad
- Nausea or vomiting
- Trouble sleeping
- Redness, pain, swelling, or itching where the shot was given
- Weakness, pain
- Weight gain
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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