Lomitapide (By mouth)
Lowers cholesterol levels.
JuxtapidThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to lomitapide. Do not use this medicine if you have active liver disease, moderate or severe liver impairment, or if you are pregnant or planning to become pregnant. Do not use this medicine if you also use any of the following: aprepitant (Emend®), boceprevir (Victrelis®), conivaptan (Vaprisol®), crizotinib (Xalkori®), diltiazem (Cardizem®), imatinib (Gleevec®), mibefradil (Posicor®), nefazodone (Serzone®), telaprevir (Incivek®), verapamil (Calan®), medicine to treat infections (such as ciprofloxacin, clarithromycin, erythromycin, fluconazole, itraconazole, ketoconazole, posaconazole, telithromycin, voriconazole, Nizoral®), or medicine to treat HIV/AIDS (such as amprenavir, atazanavir, darunavir/ritonavir, fosamprenavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Kaletra®, Norvir®, Reyataz®).
How to Use This Medicine:
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- Take this medicine without food, at least 2 hours after your evening meal.
- Swallow the capsule whole with a glass of water. Do not break, crush, chew, dissolve, or open it. If you cannot swallow the capsules, tell your doctor right away.
- Carefully follow your doctor's instructions about a low-fat diet. This medicine is part of a complete plan to lower your cholesterol.
- Your doctor will want you to take supplements (such as vitamin E, essential fatty acids) while you are using this medicine.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.If you stop taking this medicine for more than a week, call your doctor before you start taking it again.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using other medicine to lower cholesterol (such as atorvastatin, lovastatin, simvastatin, Lipitor®, Zocor®) or a blood thinner (such as warfarin, Coumadin®, Jantoven®). Tell your doctor if you also use acetaminophen (Tylenol®), alprazolam (Xanax®), aliskiren (Tekturna®), ambrisentan (Letairis®), amiodarone (Cordarone®), amlodipine (Norvasc®), bicalutamide (Casodex®), cilostazol (Pletal®), cimetidine (Tagamet®), colchicine (Tracleer®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), dabigatran etexilate (Pradaxa®), digoxin (Lanoxin®), everolimus (Zortress®), fexofenadine (Allegra®), fluoxetine (Prozac®), fluvoxamine (Luvox®), ginkgo, goldenseal, isoniazid (Nydrazid®), isotretinoin (Accutane®), lapatinib (Tykerb®), maraviroc (Selzentry®), methotrexate (Trexall®), nilotinib (Tasigna®), pazopanib (Votrient®), ranitidine (Zantac®), ranolazine (Ranexa®), saxagliptin (Onglyza®), sirolimus (Rapamune®), sitagliptin (Januvia®), talinolol, tamoxifen (Nolvadex®), tetracycline (Sumycin®), ticagrelor (Brilinta®), tipranavir/ritonavir, tolvaptan (Samsca®), topotecan (Hycamtin®), zileuton (Zyflo®), or birth control pills.
- If you are also using cholestyramine (Questran®) or colesevelam (Welchol®), take it at least 4 hours before or after you take this medicine.
- Do not drink more than 1 alcoholic drink per day. Alcohol increases your risk for liver damage when used with this medicine.
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.You must have a negative pregnancy test before you will be allowed to take this medicine.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, bowel problems, pancreas problems, or a history of alcohol abuse. Tell your doctor if you have galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency.
- Check with your doctor right away if you have pain or tenderness in your upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.
- Using this medicine together with lovastatin or simvastatin may increase the risk of a serious muscle problem called myopathy. Check with your doctor right away if you have muscle pain, tenderness, or weakness, especially if you also have unusual tiredness or a fever.
- Do not change your dose or stop taking this medicine without first talking with your doctor.
- Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain
- Dark urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Fast, pounding, or uneven heartbeat
- Muscle pain, tenderness, or weakness
- Unusual tiredness or fever
If you notice these less serious side effects, talk with your doctor:
- Back pain
- Cough, runny or stuffy nose, sore throat
- Diarrhea, constipation, gas, indigestion, stomach pain, upset stomach
- Headache or dizziness
- Weight loss
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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