Lomitapide (By mouth)
Lowers cholesterol levels.
JuxtapidThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to lomitapide. Do not use this medicine if you have active liver disease, moderate or severe liver impairment, or if you are pregnant. Do not use this medicine if you also use any of the following: aprepitant (Emend®), boceprevir (Victrelis®), conivaptan (Vaprisol®), crizotinib (Xalkori®), diltiazem (Cardizem®), imatinib (Gleevec®), mibefradil (Posicor®), nefazodone (Serzone®), telaprevir (Incivek®), verapamil (Calan®), medicine to treat infections (such as ciprofloxacin, clarithromycin, erythromycin, fluconazole, itraconazole, ketoconazole, posaconazole, telithromycin, voriconazole, Nizoral®), or medicine to treat HIV/AIDS (such as amprenavir, atazanavir, darunavir/ritonavir, fosamprenavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Kaletra®, Norvir®, Reyataz®).
How to Use This Medicine:
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- Take this medicine without food, at least 2 hours after your evening meal.
- Swallow the capsule whole with a glass of water. Do not crush, break, chew, dissolve, or open it. Tell your doctor right away if you cannot swallow the capsules.
- Carefully follow your doctor's instructions about a low-fat diet. This medicine is part of a complete plan to lower your cholesterol.
- You will need to take vitamin E and essential fatty acid supplements while you use this medicine.
- This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
If a dose is missed:
- Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. If you stop taking this medicine for more than one week, call your doctor before you start taking it again.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use other medicine to lower cholesterol (such as atorvastatin, lovastatin, simvastatin, Lipitor®, Zocor®) or a blood thinner (such as warfarin, Coumadin®, Jantoven®). Tell your doctor if you also use acetaminophen (Tylenol®), aliskiren (Tekturna®), alprazolam (Xanax®), ambrisentan (Letairis®), amiodarone (Cordarone®), amlodipine (Norvasc®), bicalutamide (Casodex®), cilostazol (Pletal®), cimetidine (Tagamet®), colchicine (Tracleer®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), dabigatran etexilate (Pradaxa®), digoxin (Lanoxin®), everolimus (Zortress®), fexofenadine (Allegra®), fluoxetine (Prozac®), fluvoxamine (Luvox®), ginkgo, goldenseal, isoniazid (Nydrazid®), isotretinoin (Accutane®), lapatinib (Tykerb®), maraviroc (Selzentry®), methotrexate (Trexall®), nilotinib (Tasigna®), pazopanib (Votrient®), ranitidine (Zantac®), ranolazine (Ranexa®), saxagliptin (Onglyza®), sirolimus (Rapamune®), sitagliptin (Januvia®), talinolol, tamoxifen (Nolvadex®), tetracycline (Sumycin®), ticagrelor (Brilinta®), tipranavir/ritonavir, tolvaptan (Samsca®), topotecan (Hycamtin®), zileuton (Zyflo®), or birth control pills.
- If you are use cholestyramine (Questran®) or colesevelam (Welchol®), take it at least 4 hours before or after you take this medicine.
- Do not drink more than 1 alcoholic drink per day. Alcohol increases your risk for liver damage when used with this medicine.
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. You must have a negative pregnancy test before you will be given this medicine.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, bowel problems, pancreas problems, or a history of alcohol abuse. Tell your doctor if you have galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency.
- Check with your doctor right away if you have pain or tenderness in your upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dark urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Fast, pounding, or uneven heartbeat, chest pain
- Muscle pain, tenderness, or weakness
- Unusual tiredness, fever
If you notice these less serious side effects, talk with your doctor:
- Back pain
- Cough, runny or stuffy nose, sore throat
- Diarrhea, constipation, gas, indigestion, stomach pain, upset stomach
- Headache, dizziness
- Weight loss
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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