Cabozantinib (By mouth)
Treats thyroid cancer.
CometriqThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to cabozantinib, or if you are pregnant.
How to Use This Medicine:
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- It is best to take this medicine on an empty stomach. Do not eat for at least 2 hours before and 1 hour after you take this medicine.
- Swallow the capsule whole with a full glass (at least 8 ounces) of water. Do not crush, break, chew, or open the capsule.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:
- If you miss a dose or forget to use your medicine and it is less than 12 hours since your regular time, take it as soon as you can and take your next dose at the normal time. If you miss a dose or forget to use it, and it is more than 12 hours since your regular time, skip the missed dose and take your next dose at the normal time. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using dexamethasone (Decadron®), nefazodone (Serzone®), St John's wort, medicine to treat HIV/AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Norvir®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, rifabutin, rifampin, rifapentine, telithromycin, voriconazole, Mycobutin®, Nizoral®, Priftin®, Rifadin®, Rimactane®), or medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Tegretol®).
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- Your unborn baby could be harmed if you use this medicine while you are pregnant. Use an effective form of birth control to keep from getting pregnant. Tell your doctor right away if you think you have become pregnant while using the medicine. Use effective birth control for at least 4 months after you stop using this medicine.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney problems, liver disease, blood clotting or bleeding problems, high blood pressure, an open wound, or dental problems.
- Tell your doctor right away if you have severe stomach pain, or you gag, cough, or choke when you eat or drink. These could be symptoms of a hole that is forming in your digestive system.
- You might bleed more easily while you are using this medicine.
- Tell your doctor right away if you have sudden trouble breathing, or severe pain anywhere in your body. These could be symptoms of a heart attack, stroke, or blood clot.
- This medicine may cause wounds to heal more slowly. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
- This medicine may cause a skin problem in your hands or feet. Tell your doctor if you have a rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet, especially it this becomes severe.
- Tell your doctor right away if you have a headache, seizures, confusion, blurred vision, or other visual problems. These may be symptoms of a rare and serious brain condition.
- This medicine may cause higher levels of protein in your urine. Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments. Your doctor will also check your blood pressure on a regular basis.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, fainting
- Cloudy urine
- Numbness or weakness in your arm, or leg, or on one side of your body
- Red or dark brown urine, bloody or black, tarry stools, unexplained nosebleeds
- Rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
- Severe diarrhea or stomach pain
- Gagging, coughing, or choking when you eat or drink
- Shortness of breath, coughing up blood, pain in your lower leg (calf)
- Sudden or severe headache, confusion, problems with vision, speech, or walking
- Swelling in your hands, arms, legs, or feet
- Tightness in your jaw, mouth pain or numbness, loose teeth
- Unusual bleeding, bruising, or weakness
- Vomit that looks like coffee grounds
If you notice these less serious side effects, talk with your doctor:
- Change in hair color
- Decreased appetite, change or loss of taste, weight loss
- Mild diarrhea, constipation, nausea, vomiting, stomach pain
- Sores or white patches on your lips, mouth, or throat
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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