Ponatinib (By mouth)
Treats leukemia. This is a cancer medicine.
IclusigThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to ponatinib, or if you are pregnant.
How to Use This Medicine:
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- Swallow the tablet whole. Do not crush, break, chew, or dissolve it.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use St John's wort, conivaptan (Vaprisol®), medicine to treat hepatitis C (such as boceprevir, telaprevir, Victrelis®), medicine to treat HIV/AIDS (such as atazanavir, indinavir, lopinavir/ritonavir, maraviroc, nelfinavir, ritonavir, saquinavir, Crixivan®, Kaletra®, Norvir®, Selzentry®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, posaconazole, rifampin, telithromycin, voriconazole, Nizoral®, Rifadin®, Rimactane®), medicine to treat seizures (such as carbamazepine, phenytoin, Dilantin®, Tegretol®), medicine to treat depression (such as nefazodone, Serzone®), or stomach medicine (such as cimetidine, famotidine, lansoprazole, omeprazole, pantoprazole, ranitidine, Aciphex®, Dexilant®, Gaviscon®, Maalox®, Mylanta®, Nexium®, Pepcid®, Prevacid®, Prilosec®, Tagamet®, Zantac®).
- Tell your doctor if you also use aliskiren (Tekturna®), ambrisentan (Letairis®), colchicine (Tracleer®), dabigatran etexilate (Pradaxa®), digoxin (Lanoxin®), everolimus (Zortress®), fexofenadine (Allegra®), imatinib (Gleevec®), irinotecan (Camptosar®), lapatinib (Tykerb®), methotrexate (Trexall®), mitoxantrone (Novantrone®), nilotinib (Tasigna®), ranolazine (Ranexa®), rosuvastatin (Crestor®), saxagliptin (Onglyza®), sirolimus (Rapamune®), sitagliptin (Januvia®), sulfasalazine (Azulfidine®), tolvaptan (Samsca®), or topotecan (Hycamtin®).
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- Your unborn baby could be harmed if you use this medicine while you are pregnant. Use an effective form of birth control to keep from getting pregnant. Tell your doctor right away if you think you have become pregnant while using the medicine.
- Make sure your doctor knows if you are breastfeeding, or if you have liver disease, bleeding problems, blood clotting problems, diabetes, heart or blood vessel disease, congestive heart failure, high blood pressure, heart rhythm problems, or a history of a heart attack or stroke. Tell your doctor if you have high uric acid levels, stomach or bowel problems, or a history of pancreas problems or alcohol abuse. Tell your doctor if you are lactose intolerant.
- This medicine may cause blood clotting problems. Check with your doctor right away if you have chest pain, numbness or weakness in your arm, leg, or on one side of your body, trouble breathing, speech problems, or leg pain or swelling.
- Check with your doctor right away if you have stomach pain, pale stools or dark urine, loss of appetite, or yellow eyes or skin. These could be symptoms of a serious liver problem.
- Check with your doctor if you are rapidly gaining weight, have chest pain or discomfort, extreme tiredness or weakness, trouble breathing, an uneven heartbeat, or excessive swelling of the hands, wrists, ankles, or feet. These may be symptoms of a heart problem or fluid retention.
- Pancreatitis may occur. Tell your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
- This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
- This medicine may cause a serious reaction called tumor lysis syndrome. Call your doctor right away if you have a decrease or change in urine amount, joint pain or swelling, lower back, side, or stomach pain, rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
- Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain, trouble breathing, coughing up blood
- Dark urine or pale stools, loss of appetite, pain in your upper stomach, yellow eyes or skin
- Fast, slow, pounding, or uneven heartbeat
- Fever, chills, cough, sore throat, and body aches
- Joint pain or swelling
- Numbness or weakness in your arm or leg, or on one side of your body
- Pain in your lower leg (calf)
- Rapid weight gain, swelling in your hands, ankles, or feet
- Sudden and severe stomach pain, nausea, vomiting, and lightheadedness
- Sudden or severe headache, problems with vision, speech, or walking
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Constipation, diarrhea, stomach pain
- Decreased appetite
- Mild headache
- Muscle pain
- Rash, dry skin
- Sores or white patches on your lips, mouth, or throat
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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