Regorafenib (By mouth)
Treats colon or rectal cancer that has spread to other parts of the body. This medicine is a kinase inhibitor.
StivargaThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to regorafenib, or if you are pregnant.
How to Use This Medicine:
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- Swallow the tablet whole. Do not crush, break, or chew it.
- Take the tablet at the same time each day with a low-fat breakfast.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the tablets at room temperature, in the original container. Do not place the tablets in daily or weekly pill boxes. Keep the medicine away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. Throw away any unused medicine 28 days after you first open the bottle.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using St John's wort, medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Tegretol®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, posaconazole, rifampin, telithromycin, voriconazole, Nizoral®, Rifadin®, Rimactane®, Vfend®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- Your unborn baby could be harmed if you use this medicine while you are pregnant. The medicine may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Both men and women should use an effective form of birth control during therapy and for 2 months after the last dose. Tell your doctor right away if a pregnancy occurs within this time.
- Make sure your doctor knows if you are breastfeeding or if you have liver, heart, or bleeding problems or high blood pressure.
- This medicine may cause serious liver problems. Your doctor will need to test your liver regularly while you are using this medicine.
- This medicine may increase your risk of bleeding and slow healing of open wounds. Avoid rough sports or situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when you use sharp objects, including razors and fingernail clippers. Tell your doctor if you have a wound that will not heal.
- This medicine may cause serious heart problems. Stop taking this medicine and tell your doctor right away if you have chest pain, nausea, pain or discomfort in your arms, jaw, back, or neck, trouble breathing, unusual sweating, or vomiting.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
- Tell your doctor right away if you have sudden severe stomach pain, swelling in your abdomen, or a high fever. These could be symptoms of a serious stomach problem.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Your blood pressure needs to be monitored on a regular basis.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness
- Coughing up or vomiting blood or material that looks like coffee grounds
- Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Red or brown urine, red or black, tarry stools
- Severe headache, seizure, confusion, vision problems
- Pain, redness, blistering, or swelling on palms of your hands or the soles of your feet
- Sudden severe stomach pain or swelling, fever
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Hoarseness, voice changes
- Loss of appetite, weight loss
- Mild diarrhea
- Swelling, pain, and redness in your mouth or throat
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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