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Carfilzomib (Injection)

Carfilzomib (kar-FILZ-oh-mib)

Treats multiple myeloma.

Brand Name(s):

Kyprolis

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not receive it if you had an allergic reaction to carfilzomib, or if you are pregnant.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems.
  • You may be given medicine to help prevent reactions to the injection.
  • Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, peripheral neuropathy (a nerve problem), low blood platelet levels, or a history of herpes zoster infection (shingles). Tell your doctor if you have heart failure, angina, heart rhythm problems, or a history of heart attack.
  • This medicine may cause heart or liver problems.
  • This medicine may make you lightheaded or dizzy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you are dizzy.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, painful or difficult urination
  • Chest pain or discomfort, uneven heartbeat
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fever, chills, cough, sore throat, and body aches
  • Lightheadedness, dizziness, or fainting
  • Muscle or joint pain
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Pain, itching, or burning where your IV needle is placed
  • Rapid weight gain, swelling of your hands, ankles, or feet
  • Trouble breathing, cold sweats, bluish-colored skin
  • Unusual bleeding, bruising, tiredness, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, constipation
  • Headache, back pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014
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