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Rivaroxaban (By mouth)

Rivaroxaban (riv-a-ROX-a-ban)

This medicine is a blood thinner that treats and prevents blood clots. Also lowers the risk of stroke in patients who have atrial fibrillation.

Brand Name(s):

Xarelto

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use if you had an allergic reaction to rivaroxaban or have severe bleeding.

How to Use This Medicine:

Tablet

  • Take this medicine as directed, and take it at the same time each day.
  • 10 milligram (mg) tablet: Take with or without food.
  • 15 mg or 20 mg tablet: Take with food.
  • If you cannot swallow the tablets, you may crush the 15 mg or 20 mg tablet and mix it with applesauce. Eat some food after you swallow the mixture.
  • Tube feeding: You may crush the 15 mg or 20 mg tablets and mix the medicine in 50 milliliters (mL) of water before giving it via the tube. This must be followed by a feeding.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose:
    • Ask your doctor or pharmacist if you are not sure what to do if you miss a dose.
    • Once a day dose: If you miss a dose or forget to use your medicine, use it as soon as you can on the same day. Do not use extra medicine to make up for a missed dose.
    • Twice a day dose to treat a blood clot (15 mg tablet): If you miss a dose or forget to use your medicine, use it as soon as you can on the same day. You may take 2 doses at the same time to make up for the missed dose. This is only for people who are supposed to take a total of 30 mg per day.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how rivaroxaban works. Tell your doctor if you are using St John's wort, carbamazepine, clarithromycin, conivaptan, erythromycin, phenytoin, rifampin, medicine to treat fungus infections (such as fluconazole, itraconazole, ketoconazole), medicine to treat HIV/AIDS (such as indinavir, lopinavir, ritonavir), an NSAID pain medicine (such as aspirin, celecoxib, diclofenac, ibuprofen, naproxen), medicine that dissolves blood clots, or another blood thinner (such as clopidogrel, enoxaparin, heparin, warfarin).

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or planning to become pregnant during treatment with this medicine, or if you are breastfeeding. Tell your doctor if you have kidney disease, liver disease, bleeding problems, or an artificial heart valve.
  • This medicine may cause the following problems:
    • Bleeding problems
    • Nerve damage (possibly permanent) if you have a procedure that involves your back, such as an epidural (more likely if you had back surgery in the past)
  • Be careful to avoid injuries that could cause bleeding. Stay away from rough sports or other situations where you could be bruised, cut, or hurt. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Avoid picking your nose. If you need to blow your nose, blow it gently.
  • Do not stop using this medicine suddenly without asking your doctor. You might have a higher risk of stroke for a short time after you stop using this medicine.
  • Tell any doctor or dentist who treats you that you are using this medicine.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Chest pain, trouble breathing, or coughing up blood
  • Heavy menstrual bleeding, or vaginal bleeding
  • Pain in your lower leg (calf)
  • Red or brown urine, bloody or black, tarry stools
  • Sudden or severe headache, problems with vision, speech, or walking
  • Unusual bleeding or bruising, including frequent nosebleeds
  • Vomiting blood or material that looks like coffee grounds

If you notice these less serious side effects, talk with your doctor:

  • Mild skin rash or itching

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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