Skip to main content

Vilazodone (By mouth)

Vilazodone (vil-AZ-oh-done)

Treats depression. This medicine is a selective serotonin reuptake inhibitor (SSRI) antidepressant.

Brand Name(s):

Viibryd, Viibryd Titration Pack

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to vilazodone. Do not use this medicine and an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, Parnate®, methylene blue, or linezolid (Zyvox®) within 14 days of each other.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using St John's wort, buspirone (Buspar®), fentanyl (Sublimaze®), lithium (Eskalith®, Lithane®, Lithobid®), tramadol (Ultram®), tryptophan supplements, other medicines to treat depression (such as amitriptyline, nortriptyline, desipramine, fluoxetine, mirtazapine, paroxetine, Celexa®, Elavil®, Lexapro®, Norpramin®, Paxil®, Zoloft®), or medicine to treat migraine headaches (such as eletriptan, sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®).
  • Tell your doctor if you are using erythromycin (Ery-tab®), ketoconazole (Nizoral®), a diuretic (water pill, such as furosemide, hydrochlorothiazide, Lasix®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bleeding problems, low sodium in the blood, or a history of mania or seizures.
  • For some teenagers and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
  • This medicine may cause a serious condition called serotonin syndrome, when taken with certain medicines. Call your doctor right away if you have a fever, confusion, mental changes, restlessness, fast heartbeat, muscle spasms, trouble walking, nausea, vomiting, or diarrhea
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • After you stop using the medicine, call your doctor if you have mood or behavior changes, confusion, headaches, nausea, vomiting, seizures, tingling pain, or ringing in your ears.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Aggression, anger, hostility
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Confusion, weakness, and muscle twitching
  • Seizure
  • Trouble sleeping, increased energy, racing thoughts
  • Unusual behavior, thoughts about hurting yourself
  • Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

  • Nausea, diarrhea
  • Problems with sex

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

Copyright © 1984- Thomson Micromedex. All rights reserved.

Thomson & A.D.A.M