Treats certain types of cancer called cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL).
IstodaxThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not receive this medicine if you have had an allergic reaction to romidepsin, or if you are pregnant.
How to Use This Medicine:
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
- You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
- This medicine is usually given on day 1, day 8, and day 15 of a 28-day cycle of treatment. Each treatment takes about 4 hours. The treatment cycle repeats every 28 days, as long as you benefit from treatment and tolerate the drug.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using St. John's wort, medicine for heart rhythm problems (such as amiodarone, disopyramide, dofetilide, flecainide, procainamide, propafenone, quinidine, sotalol, Betapace®, Cardioquin®, Cordarone®, Norpace®, Quinaglute®, Procanbid®, Rythmol®, Tambocor®, or Tikosyn®), medicine to treat HIV or AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Fortovase®, Invirase®, Norvir®, or Viracept®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, telithromycin, voriconazole, Biaxin®, Ketek®, Nizoral®, or Sporanox®), or medicine to treat depression (such as nefazodone, Serzone®). Tell your doctor if you are also using dexamethasone (Decadron®), medicine for seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, or Tegretol®), medicine for tuberculosis (rifabutin, rifampin, rifapentine, Mycobutin®, Priftin®, Rifadin®, or Rimactane®), or a blood thinner (such as warfarin, Coumadin®, or Jantoven®).
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, heart rhythm problems (such as QT prolongation), high or low potassium or magnesium in the blood, or any type of infection.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
- You may get infections (including pneumonia and sepsis) more easily during treatment and up to 30 days after treatment. Tell your doctor right away if you have a fever, cough, shortness of breath, chest pain, burning when you urinate, flu-like symptoms, muscle aches, or worsening skin problems.
- This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or uneven heartbeats, chest pain, shortness of breath, or dizziness.
- This medicine may cause a serious reaction called tumor lysis syndrome. Your doctor may give you medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount; joint pain, stiffness, or swelling; lower back, side, or stomach pain; rapid weight gain; swelling of the feet or lower legs; or unusual tiredness or weakness.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate
- Chest pain or shortness of breath
- Confusion, body weakness, and muscle twitching
- Dry mouth, increased thirst, muscle cramps, nausea, or vomiting
- Fast, pounding, or uneven heartbeat
- Fever, chills, cough, sore throat, and body aches
- Increased hunger or thirst
- Lightheadedness, dizziness, or fainting
- Rapid weight gain
- Swelling in your hands, ankles, or feet
- Unusual bleeding, bruising, or weakness
- Worsening skin problems
If you notice these less serious side effects, talk with your doctor:
- Change or loss of taste
- Diarrhea, constipation, loss of appetite, or stomach pain
- Mild rash or itching skin
- Sores or white patches on your lips, mouth, or throat
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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