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Ibuprofen (Injection)

Ibuprofen (eye-bue-PROE-fen)

Treats fever and mild to severe pain. This medicine is an NSAID.

Brand Name(s):

Caldolor, Neoprofen

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction (including asthma) to ibuprofen, aspirin, or another NSAID.

How to Use This Medicine:


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines and foods can affect how ibuprofen works. Tell your doctor if you are also using any of the following:
    • Blood thinner (such as warfarin)
    • Blood pressure medicine, including a diuretic (such as furosemide or a thiazide) or an ACE inhibitor
    • Lithium
    • Methotrexate
    • Corticosteroid (such as hydrocortisone, methylprednisolone, prednisone, prednisolone, dexamethasone, hydrocortisone)

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of pregnancy.
  • Tell your doctor if you have kidney disease, liver disease, bleeding problems, high blood pressure, congestive heart failure, asthma, lupus or a similar connective tissue disorder, or a history of ulcers or other digestive problems.
  • This medicine may cause the following problems:
    • Higher risk of heart attack or stroke
    • Bleeding and ulcers in your stomach or intestines
    • High blood pressure
    • Liver damage
    • Kidney damage

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Change in how much or how often you urinate
  • Chest pain that may spread, trouble breathing, nausea, unusual sweating, fainting
  • Chest pain, trouble breathing, or coughing up blood
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fever, neck pain, stiff neck
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Rapid weight gain or swelling in your hands, ankles, or feet
  • Severe stomach pain, vomiting blood, bloody or black, tarry stools
  • Trouble seeing, blind spots, change in how you see colors
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Vomiting
  • Dizziness or lightheadedness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 3/28/2016
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