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Eltrombopag (By mouth)

Eltrombopag (el-TROM-boe-pag)

Treats thrombocytopenia in patients with chronic idiopathic thrombocytopenic purpura (ITP) and hepatitis C.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to eltrombopag.

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine on an empty stomach.Take this medicine at least 1 hour before or 2 hours after a meal.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not take more than one dose in a day.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you use bosentan (Tracleer®), doxorubicin (Adriamycin®), glyburide (Diabeta®, Glynase®, Micronase®), imatinib (Gleevec®), irinotecan (Camptosar®), lapatinib (Tykerb®), methotrexate (Rheumatrex®, Trexall®), mitoxantrone (Novantrone®), nateglinide (Starlix®), olmesartan (Benicar®), penicillin G injections, repaglinide (Prandin®), rifampin (Rifadin®, Rimactane®), sulfasalazine (Azulfidine®), topotecan (Hycamtin®), or valsartan (Diovan®). Tell your doctor if you also use a blood thinner (such as warfarin, Coumadin®, Jantoven®) or a medicine to lower cholesterol (such as atorvastatin, ezetimibe, fluvastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, Crestor®, Lescol®, Lipitor®, Pravachol®).
  • Antacids, multivitamins, or other products (such as dairy products or juices) that contain aluminum, calcium, iron, magnesium, selenium, or zinc must be taken at least 4 hours before or 4 hours after you take eltrombopag.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding or if you have kidney disease, liver disease (including cirrhosis), bleeding problems, bone marrow problems, a blood cancer, myelodysplastic syndrome (MDS), or a history of blood clots or cataracts.
  • Check with your doctor right away if you have nausea or vomiting, dark urine, pale stools, pain in your upper stomach, unusual tiredness, or yellow eyes or skin. These may be signs of a serious liver problem.
  • Patients who are Asian or have Asian relatives may need lower doses of this medicine.
  • This medicine may cause changes in your blood marrow. These changes may cause your body to make fewer blood cells. You will need blood tests to check for this.
  • Blood clotting problems may occur while you use this medicine. Check with your doctor right away if you have pain, swelling, or tenderness in your leg, trouble breathing, or chest pain.
  • This medicine may cause cataracts or make them worse. Check with your doctor right away if you have blurred vision, difficulty reading, or any other change in your vision.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor will also check your blood for a few weeks after you stop using this medicine.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision or changes in vision
  • Change in how much or how often you urinate, burning or painful urination
  • Chest pain, trouble breathing, or coughing up blood
  • Dark-colored urine, pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Pain in your lower leg (calf)
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Sudden or severe headache or problems with vision, speech, or walking
  • Unusual bleeding, bruising, tiredness, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Joint or muscle pain
  • Mild nausea, vomiting, diarrhea

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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