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Certolizumab (Injection)

Certolizumab Pegol (ser-toe-LIZ-oo-mab PEG-ol)

Treats Crohn disease, rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

Brand Name(s):

Cimzia

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use if you had an allergic reaction to certolizumab.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. Usually given in the abdomen or upper thighs.
  • A nurse or other health provider will give you this medicine.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • The medicine should be clear to slightly yellow in color. Do not use the medicine if it is cloudy or discolored, or has large particles in it.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Call your doctor or pharmacist for instructions.
  • If you store this medicine at home, keep it in the refrigerator. Do not freeze. Protect the medicine from direct light. Keep your medicine in the original package until you are ready to use it.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how certolizumab works. Tell your doctor if you are using abatacept, adalimumab, anakinra, etanercept, natalizumab, rituximab, methotrexate, or a steroid medicine (such as dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone).
  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, cancer, congestive heart failure, blood or bone marrow problems, or any type of infection, including hepatitis, tuberculosis, or hepatitis B. Tell your doctor if you have a history of Guillain-Barré syndrome, multiple sclerosis, or a similar nervous system problem.
  • This medicine may cause the following problems:
    • Higher risk of infection (including bacteria, virus, or fungus infections)
    • Cancer (such as lymphoma, leukemia, skin cancer)
    • Congestive heart failure
    • Lupus-like syndrome
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, bloody or cloudy urine, painful urination
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Joint pain, rash on the cheeks or arms that is sensitive to the sun
  • Seizure, vision problems, or numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Swelling in your hands, ankles, or feet, trouble breathing, tiredness
  • Swollen lymph glands in your neck, armpits, or groin
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Redness, pain, or swelling where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014
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