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Sitagliptin/metformin (By mouth)

Metformin Hydrochloride (met-FOR-min hye-droe-KLOR-ide), Sitagliptin Phosphate (sit-a-GLIP-tin FOS-fate)

Treats type 2 diabetes.

Brand Name(s):

Janumet, Janumet XR

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to metformin or sitagliptin, or if you have kidney disease or metabolic acidosis (including diabetic ketoacidosis).

How to Use This Medicine:

Tablet, Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk.
  • Extended-release tablet:
    • Take as directed in the evening.
    • While taking this medicine, you may see tablets in your stools. If you see tablets in your stool several times, tell your doctor right away.
  • Swallow the tablet whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how metformin/sitagliptin works. Tell your doctor if you are using the following:
    • acetazolamide, cimetidine, dichlorphenamide, isoniazid, niacin (vitamin B3), phenytoin, topiramate, zonisamide
    • a diuretic
    • blood pressure medicine, such as a calcium channel blocker
    • estrogen hormones or birth control pills
    • phenothiazine medicine, such as chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine
    • steroid medicine, such as hydrocortisone, methylprednisolone, prednisone, dexamethasone
    • thyroid hormone replacement

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney problems, liver disease, adrenal or pituitary problems, congestive heart failure, heart disease, gallstones, high cholesterol, vitamin B12 deficiency, or a history of pancreas problems. Tell your doctor if you drink alcohol.
  • This medicine may cause the following problems:
    • Pancreatitis
    • Lactic acidosis
    • Kidney problems, sometimes requiring dialysis
    • Low blood sugar
    • Serious allergic reactions (including skin reactions)
  • Tell your doctor if you become injured or sick, especially if you are dehydrated or have an infection, severe vomiting, diarrhea, or fever. Also tell your doctor if you are having surgery. Your doctor may make changes to your medicine for a short time.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Fast breathing, trouble breathing, nausea and vomiting, lightheadedness, severe weakness, tiredness, or confusion
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
  • Sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness

If you notice these less serious side effects, talk with your doctor:

  • Cough, runny or stuffy nose, or sore throat
  • Diarrhea, mild stomach pain, or upset stomach
  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014
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