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Posaconazole (By mouth)

Posaconazole (poe-sa-KON-a-zole)

Prevents certain fungus infections in patients who have a weakened immune system. Also treats an infection in the mouth or throat called oral thrush. This is an antifungal medicine.

Brand Name(s):

Noxafil

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to posaconazole or to other similar medicines (such as fluconazole, itraconazole, ketoconazole, voriconazole, Diflucan®, Nizoral®, Sporanox®, Vfend®). Do not use this medicine if you are also using atorvastatin (Lipitor®), lovastatin (Mevacor®), pimozide (Orap®), quinidine (Quinaglute®), simvastatin (Zocor®), sirolimus (Rapamune®), or ergotamine medicines (such as bromocriptine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, methysergide, Cafergot®, Ergomar®, Wigraine®).

How to Use This Medicine:

Liquid

  • Take your medicine as directed.
  • Take this medicine with a full meal or up to 20 minutes after a meal. If you cannot eat a full meal, take it with a liquid nutritional supplement or an acidic beverage, such as ginger ale.
  • Shake the oral liquid well before using. Use the dosing spoon in the package to measure the dose. Rinse the measuring spoon with water after using and before storage.
  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you use alprazolam (Xanax®), atazanavir (Reyataz®), cimetidine (Tagamet®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), digoxin (Digitek®, Lanoxin®), efavirenz (Sustiva®), esomeprazole (Nexium®), fosamprenavir (Lexiva®), glipizide (Glucotrol®), metoclopramide (Reglan®), midazolam (Versed®), phenytoin (Dilantin®), rifabutin (Mycobutin®), ritonavir (Norvir®), tacrolimus (Prograf®, Protopic®), triazolam (Halcion®), vinblastine (Velban®), or vincristine (Oncovin®, Vincasar®). Tell your doctor if you also use blood pressure medicines, such as diltiazem, felodipine, nicardipine, nifedipine, verapamil, Cardene®, Lotrel®, Norvasc®.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have a history of heart disease, heart rhythm problems (such as arrhythmia, QT prolongation), kidney disease, liver disease, or low potassium, magnesium, or calcium in your blood.
  • Tell your doctor if you have severe diarrhea or vomiting while you are using this medicine.
  • This medicine can cause serious heart rhythm problems. Tell your doctor right away if you notice a change in your heart rhythm, such as fast, pounding, or uneven heartbeats.
  • Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow skin or eyes. These could be symptoms of a serious liver problem.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, or coughing up blood
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Dry mouth, increased thirst, muscle cramps
  • Fast, slow, pounding, or uneven heartbeat
  • Fever, chills, cough, stuffy or runny nose, sore throat, and body aches
  • Lightheadedness, dizziness, or fainting
  • Pinpoint red or purple spots under your skin
  • Severe diarrhea or vomiting
  • Swelling in your hands, legs, ankles, or feet
  • Tiny red dots on the skin, especially on the lower legs
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Back, joint, muscle pain
  • Constipation, mild diarrhea, stomach pain, or upset stomach
  • Headache
  • Nosebleeds
  • Skin rash, itching
  • Trouble sleeping, anxiety

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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