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Immune globulin subcutaneous (Injection)

Immune Globulin (i-MUNE GLOB-ue-lin)

Treats problems with your immune system. Helps prevent infections or makes the infection less severe. Increases the amount of immune globulin in people who do not have enough in their bodies.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to immune globulin or polysorbate 80. You should not receive this medicine if you have hyperprolinemia (too much proline in the blood) or a history of immunoglobulin A (IgA) deficiency with antibodies against IgA and a history of hypersensitivity.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use a new needle and syringe each time you inject your medicine.
  • Allow the Gammagard Liquid or Gamunex®-C brand to reach room temperature before you use it, if you kept it in the refrigerator.
  • Do not use the medicine if it has changed color or has flecks (particles) floating in it. Do not heat up or shake the medicine.
  • Keep a treatment diary or logbook that contains information about each injection, such as time, date, dose, and any reactions.
  • Do not change the brand or type of your immune globulin unless your doctor tells you to. If you must change the brand or type of medicine, talk to your doctor before injecting.

If a dose is missed:

  • You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

How to Store and Dispose of This Medicine:

  • Store your medicine in the original container. Always check the expiration date.
  • If you store your medicine at home:
    • Gamunex®-C should be stored in the refrigerator, but do not freeze the medicine.
    • Hizentra® should be stored at room temperature, away from heat and direct light.
    • Gammagard Liquid may be stored in the refrigerator or at room temperature. Do not freeze. Talk with your pharmacist if you have questions about storage of this product.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. Throw away old medicine after the expiration date has passed. Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows about any medicine you use that affects your kidneys.
  • Talk to your doctor before you get any vaccine while you are receiving immune globulin. Some vaccines may not work as well while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney problems, diabetes, hyponatremia (low sodium in the blood), or a serious infection.
  • Make sure your doctor knows about any heart disease or blood, circulation, or blood clotting problems that you have. Blood clots and heart attacks have happened in some patients. Tell your doctor if you have atherosclerosis, a history of heart attack or stroke, anemia, idiopathic thrombocytopenic purpura (ITP), or protein problems such as paraproteinemia or hyperproteinemia. Your may have a higher risk if you are obese, use estrogen medicine, have diabetes, or must stay in bed for a long time because of surgery or illness.
  • Call your doctor if you have any unusual symptoms that concern you, such as a fever, trouble breathing, less urine than usual, dark urine, unusual tiredness, severe pain, swelling, or fast heartbeat. Rarely, this medicine may cause serious problems with your kidneys or blood.
  • Call your doctor right away if you have trouble breathing, chest pain, and fever. Also call if your lips or hands turn blue or darker than normal. These may be signs of a serious lung problem. This may begin within 6 hours after your infusion.
  • Call your doctor right away if you have a severe headache, especially if you also have nausea or vomiting, and if you have a stiff neck, eye pain, or your eyes are sensitive to light. These could be symptoms of a serious condition called aseptic meningitis syndrome (AMS). This may begin as long as 2 days after treatment.
  • This medicine is made from donated human blood. Some human blood products have transmitted viruses, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor about this risk if you are concerned.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blue lips or fingers
  • Change in how much or how often you urinate
  • Chills, cough, sore throat, nausea, vomiting during the infusion
  • Dark, red, or brown urine
  • Fast, pounding, or uneven heartbeat
  • Fever higher than 100 degrees Fahrenheit
  • Lightheadedness, dizziness
  • Pain in your lower leg (calf), numbness or weakness in your arm or leg or on one side of your body
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Severe back, stomach, chest, or side pain
  • Stiff neck, headache, nausea, vomiting, fever, eye pain, eye sensitivity to light
  • Sudden or severe headache, problems with vision, speech, or walking
  • Trouble breathing
  • Unusual bleeding, bruising, or weakness
  • Yellow eyes or skin

If you notice these less serious side effects, talk with your doctor:

  • Low fever
  • Mild headache or pain
  • Pain, itching, burning, redness, swelling, warmth, or a lump under your skin where the shot is given
  • Warmth or redness in the face, neck, arms, or upper chest

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/4/2014
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