Deferasirox (By mouth)
Treats iron toxicity. This medicine is an iron chelator (binder).
ExjadeThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. Do not use it if you had an allergic reaction to deferasirox, or if you have severe kidney disease, severe liver disease, cancer, or blood or bone marrow problems (such as myelodysplastic syndrome, low platelet counts).
How to Use This Medicine:
Tablet for Suspension
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. It is best to take this medicine at the same time each day on an empty stomach, at least 30 minutes before you eat.
- Dissolve the tablet for suspension in water, orange juice, or apple juice. Mix well and drink the mixture right away. To make sure you get all of the medicine, add more liquid to the glass, and then drink all of this liquid too. Do not chew or swallow the tablet whole.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines and foods can affect how deferasirox works. Do not take this medicine and antacids that contain aluminum at the same time. Tell your doctor if you drink coffee or use products that contain caffeine.
- Tell your doctor if you are using alfentanil, alosetron, aprepitant, buspirone, conivaptan, cyclosporine, darifenacin, dasatinib, dronedarone, duloxetine, eletriptan, eplerenone, everolimus, felodipine, fentanyl, lurasidone, melatonin, midazolam, nisoldipine, paclitaxel, pimozide, quetiapine, quinidine, repaglinide, rifampicin, ramelteon, sildenafil, sirolimus, tacrine, tacrolimus, theophylline, tizanidine, tolvaptan, triazolam, or vardenafil.
- Also tell your doctor if you are using an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen), ergot medicines (such as dihydroergotamine, ergotamine), a steroid medicine (such as budesonide, fluticasone, prednisolone, prednisone), medicine to treat bone diseases or a bisphosphonate medicine, medicine to treat HIV (such as darunavir, indinavir, lopinavir, maraviroc, ritonavir, saquinavir, tipranavir), medicine to lower cholesterol (such as cholestyramine, colesevelam, colestipol, lovastatin, simvastatin), medicine to treat seizures (such as phenobarbital, phenytoin), birth control pills, or a blood thinner (such as ticagrelor, warfarin).
Warnings While Using This Medicine:
- Make sure your doctor knows if you are pregnant or breastfeeding or if you have kidney disease, liver disease, eye problems (such as cataracts, glaucoma), hearing problems, or stomach or bowel problems (such as ulcers or bleeding).
- This medicine can cause the following problems:
- Kidney problems, including kidney failure
- Liver problems
- Stomach or bowel bleeding (may be life-threatening)
- Anemia or other problems with blood cell counts
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash
- Dark urine or pale stools, yellow skin or eyes
- Decrease in how much or how often you urinate, bloody or cloudy urine
- Fever, chills, cough, sore throat, and body aches
- Rapid weight gain, swelling in your face, hands, ankles, or feet
- Red or black stools
- Severe nausea, vomiting, diarrhea, stomach pain
- Unusual bleeding, bruising, or weakness
- Vomiting of blood or material that looks like coffee grounds
If you notice these less serious side effects, talk with your doctor:
- Hearing problems or loss of hearing
- Mild nausea, vomiting, diarrhea, stomach pain
- Mild rash
- Vision changes
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 11/4/2014
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