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Esomeprazole (Injection)

Esomeprazole (es-oh-MEP-ra-zole)

Treats gastroesophageal reflux disease (GERD) in patients who are temporarily unable to take the oral form of this medicine. This medicine is a proton pump inhibitor (PPI).

Brand Name(s):

Nexium I.V.

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to esomeprazole or similar medicines, such as omeprazole, lansoprazole, pantoprazole, Aciphex®, Prevacid®, or Protonix®.

How to Use This Medicine:


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use cilostazol (Pletal®), clopidogrel (Plavix®), digoxin (Lanoxin®), erlotinib (Tarceva®), ketoconazole (Nizoral®), methotrexate (Rheumatrex®, Trexall®), rifampin (Rifadin®, Rimactane®), tacrolimus (Prograf®), voriconazole (Vfend®), iron supplements, St John's wort, a blood thinner (such as warfarin, Coumadin®, Jantoven®), or medicine to treat HIV infection (such as atazanavir, nelfinavir, saquinavir, Reyataz®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, osteoporosis, or a history of low magnesium levels in your blood.
  • This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you use this medicine longer than 1 year, or if you use it with digoxin or certain diuretics (water pills). Check with your doctor right away if you have seizures, dizziness, a fast or pounding heartbeat, or muscle spasms.
  • You may be at risk for Clostridium difficile colitis (also called C diff) if you take this medicine. Your risk is higher if you are also using antibiotics. Tell your doctor right away if you have diarrhea that does not go away, stomach pain, and fever.
  • Ask your doctor before you take any medicine to stop severe diarrhea.
  • This medicine may increase your risk of broken bones in the hip, wrist, and spine. This is more likely if you are older than 50, if you receive high doses of this medicine, or you use it for longer than 1 year.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Fast, slow, pounding, or uneven heartbeat
  • Seizures, dizziness, muscle spasms, muscle cramps or twitching
  • Severe diarrhea that does not go away, stomach pain, and fever

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild diarrhea, nausea, gas, stomach pain
  • Redness, pain, itching, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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