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Pregabalin (By mouth)

Pregabalin (pre-GA-ba-lin)

Treats nerve and muscle pain caused by diabetes, shingles, fibromyalgia, or a spinal cord injury. Also treats partial-onset seizures in adults.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to pregabalin.

How to Use This Medicine:

Capsule, Liquid

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Pregabalin may be used together with other seizure medicines. Keep using all of your medicines unless your doctor tells you to stop.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using diabetes medicine that you take by mouth (such as pioglitazone, rosiglitazone, Actoplus Met®, Actos®, Avandia®) or an ACE inhibitor (blood pressure medicine, such as benazepril, enalapril, lisinopril, Lotrel®, Vasotec®, Zestoretic®, Zestril®).
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine. Tell your doctor if you are also using a pain medicine (such as oxycodone, OxyContin®) or medicine for anxiety (such as lorazepam, Ativan®).
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, heart failure, heart rhythm problems, diabetes, edema (swelling caused by fluid retention), a bleeding disorder, or low numbers of blood platelets. Tell your doctor if you have a history of alcohol or drug abuse.
  • Make sure your doctor knows if you have had depression or other mood problems. This medicine may cause unusual thoughts or behavior, such as agitation, anger, or extreme happiness. It may also cause worsened depression, or suicidal thoughts and behavior. Tell your doctor right away if you or your caregiver notice any sudden or unusual mood or thought changes.
  • Tell your doctor right away if you have any unexplained muscle pain, tenderness, or weakness, especially with a fever or a general ill feeling.
  • This medicine may make you dizzy or drowsy. It may also cause blurry or double vision. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurry or double vision
  • Fever, chills, cough, sore throat, and body aches
  • Muscle pain, soreness, weakness with fever or general ill feeling
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Severe dizziness or drowsiness
  • Sudden mood changes, unusual thoughts or behavior such as extreme happiness or depression
  • Suicidal thoughts or behavior
  • Swelling in your throat, head, or neck
  • Uneven heartbeat
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Confusion, trouble concentrating
  • Dry mouth, constipation
  • Mild tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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