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Clofarabine (Injection)

Clofarabine (kloe-FAR-a-been)

Treats leukemia. This is a cancer medicine.

Brand Name(s):

Clolar

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to clofarabine, or if you are pregnant.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney or liver disease. Tell your doctor if you have had a hematopoietic stem cell transplant (HSCT).
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • This medicine may cause high uric acid levels in the blood or tumor lysis syndrome. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness.
  • Call your doctor right away if you have dizziness, faintness, or lightheadedness, a fast or uneven heartbeat, trouble breathing, or swelling of the hands, ankles, feet, or lower legs. These may be symptoms of rare but serious conditions called capillary leak syndrome or systemic inflammatory response syndrome (SIRS).
  • Check with your doctor right away if you have stomach pain, pale stools or dark urine, loss of appetite, or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Blue lips and fingernails, increased sweating, pale skin
  • Change in how much or how often you urinate
  • Chest tightness, trouble breathing, rapid shallow breathing
  • Dark urine or pale stools, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat
  • Fever, chills, cough, sore throat, and body aches
  • Lightheadedness, dizziness, or fainting
  • Rapid weight gain, swelling of your hands, ankles, feet, or face
  • Red or brown urine
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Anxiety
  • Headache
  • Nosebleeds, bleeding from your gums
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • Small red spots under your skin, rash, or itchy skin
  • Vomiting, diarrhea, stomach pain, loss of appetite
  • Warmth or redness of your face, neck, arm, or upper chest

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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