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Darifenacin (By mouth)

Darifenacin (dar-i-FEN-a-sin)

Treats symptoms of an overactive bladder such as incontinence (loss of bladder control) or a frequent need to urinate by helping you have more control over the need to urinate.

Brand Name(s):

Enablex

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to darifenacin. You should not use this medicine if you have problems passing urine, have a narrow-angle glaucoma that is not under control, or have problems with food emptying from your stomach (gastric retention).

How to Use This Medicine:

Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • You may take this medicine with or without food.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.Take your medicine with a full glass of water.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using clarithromycin (Biaxin®), flecainide (Tambocor?), itraconazole (Sporanox®), ketoconazole (Nizoral®), nefazodone (Serzone®), nelfinavir (Viracept®), ritonavir (Kaletra®, Norvir®), or thioridazine (Mellaril®). Tell your doctor if you are also using medicine for depression, such as amitriptyline, doxepin, nortriptyline, Elavil®, Pamelor®, or Sinequan®.
  • Tell your doctor if you are using atropine, dicyclomine (Bentyl®), glycopyrrolate (Robinul®), hyoscyamine (Cystospaz®), propantheline (Pro-Banthine®), or scopolamine (Transderm Scop®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease (including cirrhosis), myasthenia gravis (severe muscle weakness), narrow-angle glaucoma, or stomach or bowel problems (such as constipation or ulcerative colitis).
  • While you are using this medicine, you may be more sensitive to heat. You could develop heat exhaustion, especially when you exercise or are outdoors on a hot day. Drink extra water while you are in a hot environment, and try to avoid getting too hot.
  • This medicine may make you dizzy or drowsy, or cause blurred vision. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert or not able to see well.
  • This medicine may cause constipation. Call your doctor if you get severe stomach pain or become constipated.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Decrease in how much or how often you urinate, or difficult urination
  • Fever, chills, cough, sore throat, and body aches
  • Rapid weight gain
  • Swelling in your hands, ankles, or feet
  • Unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision
  • Constipation, stomach upset
  • Dry mouth
  • Headache, confusion, drowsiness, or hallucinations (seeing, hearing, or feeling things that are not there)

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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