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Hyaluronidase (Injection)

Hyaluronidase (hye-al-ure-ON-i-dase)

Helps your body absorb medicines that are injected into your skin. Also helps your body absorb radioactive substances during subcutaneous urography.

Brand Name(s):

Hylenex, Vitrase

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to hyaluronidase, thimerosal, or beef proteins.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
  • A nurse or other health provider will give you this medicine.
  • You may be given a skin test to make sure you are not allergic to the medicine before you receive it for the first time.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use dopamine (Intropin®), furosemide (Lasix®), phenytoin (Dilantin®), or a sedative (such as alprazolam, clonazepam, diazepam, lorazepam, Valium®, Xanax®).
  • Tell your doctor if you use aspirin or similar medicines such as Asacol®, Colazal®, Dipentum®, Pentasa®, or Rowasa®. Tell your doctor if you are using cold or allergy medicine, a hormone medicine (such as estrogen), or a steroid medicine (such as cortisone).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, if you have other medical problems, or if you have any infection at the injection site.
  • This medicine is made from donated human blood. Some human blood products have transmitted viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor about this risk if you are concerned.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chills, dizziness, nausea, vomiting
  • Fast heartbeat
  • Lightheadedness or fainting
  • Swelling in your hands, ankles, or feet

If you notice these less serious side effects, talk with your doctor:

  • Mild skin rash, redness, or itching
  • Pain, itching, burning, redness, swelling, or a lump under your skin where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/4/2014
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