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Procainamide (Injection)

Procainamide (proe-KANE-a-mide)

Treats arrhythmias or heart rhythm problems.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have an allergy to procainamide. You should not use this medicine if you have a disease called lupus, or certain types of heart disease.

How to Use This Medicine:


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using digoxin, Lanoxin®, or Digitek®.
  • Make sure your doctor knows if you use any medicines to control heart rhythm such as disopyramide, quinidine, Cardioquin®, Norpace®, or Quinaglute®.
  • Make sure your doctor knows if you are using aspirin, atropine, dicyclomine, or Bentyl®. Tell your doctor if you use glycopyrrolate, scopolamine, Robinul®, or Transderm Scop®.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding.
  • Make sure your doctor knows if you have congestive heart failure or kidney disease. Tell your doctor if you have liver disease or a muscle disease such as myasthenia gravis.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain or chest tightness.
  • Dark-colored urine or pale stools.
  • Fast, pounding, or uneven heart beats.
  • Fever, chills, cough, sore throat, or body aches.
  • Light-headedness or fainting.
  • Pain in your upper stomach, nausea, vomiting, or loss of appetite.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Bitter taste in your mouth.
  • Dizziness, tiredness, or weakness.
  • Depression or agitation.
  • Mild nausea, vomiting, diarrhea, constipation, or stomach pain.
  • Mild skin rash or itching.
  • Pain in your joints.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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