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Buprenorphine/naloxone (By mouth)

Buprenorphine Hydrochloride (bue-pre-NOR-feen hye-droe-KLOR-ide), Naloxone Hydrochloride (nal-OX-one hye-droe-KLOR-ide)

Treats an addiction to or dependence on narcotic medicine.

Brand Name(s):

Suboxone, Zubsolv

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to buprenorphine or naloxone.

How to Use This Medicine:

Thin Sheet, Tablet

  • You will have serious side effects if you take too much of this medicine. If you do not understand the directions or warnings, ask your doctor.
  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • You must let the medicine dissolve under your tongue. Never swallow the film or tablet. Your body may not absorb enough of the medicine if you swallow it.
  • Your health caregiver should show you how to use the medicine. If you do not understand, ask for help. It is important to use the medicine correctly. Do not talk while the medicine is in your mouth.
  • Tablet: Place the tablet under your tongue. If your doctor told you to use more than 1 tablet, place all of the tablets under your tongue together. You can use 2 tablets at a time until you have taken all of the medicine, if that is easier for you. Let the tablets dissolve completely in your mouth. Do not eat or drink anything until the tablets are completely dissolved.
  • Film: Place the film under your tongue. If your doctor told you to use more than 1 film, place the second film on the opposite side from the first one. Do not move the film after you place it under your tongue. If you are supposed to use more than 2 films, use them the same way, but do not start until the first 2 films are completely dissolved.
  • Do not break, crush, chew, or cut the film or tablet.
  • You should always get the same form and strength of medicine every time you fill the prescription, unless your doctor told you that it will change. Tell the pharmacist if your medicine is different than what you expected.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.Flush any unused Zubsolv® tablets down the toilet.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.This medicine could cause death in a child.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using a tranquilizer or benzodiazepine (such as alprazolam, clonazepam, diazepam, lorazepam, or Xanax®). Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
  • Make sure your doctor knows if you are using an antibiotic (such as erythromycin, Ery-tab®), medicine to treat a fungus infection (such as itraconazole, ketoconazole, Nizoral®), or medicine to treat HIV/AIDS (such as atazanavir, delavirdine, efavirenz, etravirine, nevirapine, Atripla®, Crixivan®, Intelence®, Lexiva®, Prezista®, Rescriptor®, Reyataz®, Sustiva®, Viramune®).
  • Tell your doctor if you are also using carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or rifampicin (Rifadin®, Rimactane®).
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding. This medicine could cause side effects in your baby if you use it while pregnant or breastfeeding.
  • Tell your doctor if you have kidney disease, liver disease (including hepatitis), an adrenal problem such as Addison disease, enlarged prostate, gallbladder problems, digestion problems, trouble urinating, or low thyroid levels.
  • Make sure your doctor knows if you have any kind of breathing problem, such as chronic obstructive pulmonary disease (COPD) or a curved spine that interferes with breathing. Make sure your doctor knows if you have had a recent head injury, brain tumor, or other problem that could increase the pressure in your head.
  • An overdose of this medicine can cause death. Symptoms of overdose include trouble breathing, slow or shallow breathing, severe dizziness or weakness, slow heartbeat, fainting, pinpoint pupils, or severe sleepiness.
  • Make sure your doctor knows about all drug or alcohol problems you or your family members have. Also tell your doctor about any mental or emotional problems.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine.
  • Never inject this medicine. It will cause serious health problems if injected.
  • It is against the law and dangerous for anyone else to use your medicine. Always keep your medicine in a secure place so no one can steal it.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machine, or doing anything else that could be dangerous until you know how this medicine affects you. You may also feel lightheaded when standing up suddenly from a sitting or lying position, so get up slowly.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Lightheadedness, dizziness, fainting
  • Severe headache
  • Severe stomach pain
  • Trouble breathing, slow or shallow breathing, sighing, or extreme weakness or sleepiness

If you notice these less serious side effects, talk with your doctor:

  • Headache, trouble sleeping
  • Mild stomach pain, constipation, upset stomach
  • Shaking, sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, vomiting, and muscle aches
  • Sweating

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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