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Clonidine (Injection)

Clonidine (KLOE-ni-deen)

Treats severe pain caused by cancer.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to clonidine. You should not receive this medicine if you have bleeding disorders or if you are using a blood thinner such as warfarin (Coumadin®).

How to Use This Medicine:


  • This medicine is given through a needle placed in your spinal cord.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using blood pressure medicine such as beta blockers (atenolol, metoprolol, propranolol, Toprol®, or Inderal®) or calcium channel blockers (such as verapamil, nifedipine, Lotrel®, or Norvasc®).
  • Make sure your doctor knows if you are using medicine to treat depression, such as amitriptyline, nortriptyline, Elavil®, Pamelor®, or Sinequan®.
  • Make sure your doctor knows if you are using medicines such as digoxin (Lanoxin®) or fluphenazine.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding.
  • Make sure your doctor knows if you have kidney disease or heart disease.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Make sure that you don't stop taking this medicine without first talking with your doctor to make sure it is okay
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Decrease in how much or how often you urinate.
  • Dizziness, drowsiness, or headache.
  • Fast or slow heartbeat
  • Fever, chills, cough, or sore throat.
  • Lightheadedness or fainting.
  • Severe stomach pain, nausea, or vomiting.
  • Trouble breathing or chest pain.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision or dry eyes.
  • Constipation.
  • Loss of appetite.
  • Loss of interest in sex
  • Loss of hair or sweating.
  • Mild skin rash or itching.
  • Pain in your joints, muscle cramps.
  • Redness, pain, swelling, or rash at the site of injection .
  • Ringing in your ears.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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