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Mepenzolate (By mouth)

Mepenzolate (me-PEN-zoe-late)

Treats peptic ulcers.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to mepenzolate, or to related medicines such as atropine, belladonna, Levsin®, or scopolamine. You should not receive this medicine if you have glaucoma, or if you have myasthenia gravis. You should not receive this medicine if you have certain blockage problems of your urinary tract, or if you have blockage or poor movement of your gastrointestinal tract. You should not use this medicine if your heart is not working properly due to serious bleeding in your gastrointestinal tract.

How to Use This Medicine:


  • Take your medicine as directed. It is best to take this medicine with meals and at bedtime.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Keep the bottle tightly closed when not using it. Store at room temperature, away from heat and direct light.Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using other medicine that makes you drowsy such as sleeping pills, cold and allergy medicine, anxiety medicine, or narcotic pain killers. Also make sure your doctor knows if you are using medicine to treat vomiting or mental problems such as prochlorperazine (Compazine®), Mellaril®, Phenergan®, Thorazine®, or haloperidol (Haldol®).
  • Tell your doctor if you are using medicine for depression or other health problems, such as amitriptyline (Elavil®), nortriptyline (Sinequan®), or doxepin (Pamelor®). Make sure your doctor knows if you are taking medicine for heart problems, such as quinidine (Cardioquin®, Quinaglute®) or nitroglycerin (IMDUR®, Isordil®). Tell your doctor if you are using an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate®, if you are taking amantadine (Symmetrel®), or if you are taking medicine for glaucoma. There are many other drugs that can interact with mepenzolate. Make sure your doctor knows about all other medicines you are using.
  • Avoid using antacids while you are using mepenzolate.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have liver or kidney disease. Tell your doctor if you have heart disease or heart rhythm problems, high blood pressure, or if you have a disease that affects your nervous system. Make sure your doctor knows if you have a hiatal hernia, reflux esophagitis, megacolon, ulcerative colitis, an ileostomy or colostomy, diarrhea, or other problems with your bowel or stomach. Tell your doctor if you have glaucoma, enlarged prostate, thyroid problems, or trouble urinating. Make sure your doctor knows if you have had an allergic reaction to yellow food dye (FD&C Yellow No. 5, tartrazine), or to aspirin. Tell your doctor about any other medical problems you may have.
  • This medicine may keep you from sweating enough, which may cause your body to get too hot. Be careful in hot weather, or while doing activities such as exercising or using a sauna or whirlpool.
  • This medicine may make you drowsy, dizzy, or cause you to have blurred vision. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Confusion, hallucinations (sensing things that are not there), or extreme behavior changes.
  • Drowsiness or fainting.
  • Heartbeat that is too fast, too slow, uneven, or pounding.
  • Large pupils (round, black part of the center of your eye), eyes sensitive to light.
  • Muscle weakness or new trouble with movement.
  • Nausea, vomiting, diarrhea, constipation, swollen belly, or pain in the stomach.
  • Severe dry mouth that causes trouble swallowing or speaking.
  • Trouble urinating, or a decrease in how much or how often you urinate.
  • Decreased sweating, feeling overheated, skin that is red or hot, or having a fever.

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision.
  • Dry mouth, loss of taste.
  • Headache, nervousness.
  • Impotence (problems having an erection).
  • Trouble sleeping.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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