Skip to main content

Prochlorperazine (Injection)

Prochlorperazine Edisylate (proe-klor-PER-a-zeen e-DIS-i-late)

Treats severe nausea and vomiting. Also used to treat anxiety and some psychiatric disorders.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not be given this medicine if have ever had an allergic reaction to prochlorperazine or any other phenothiazine medicine, such as Mellaril®, Phenergan®, Thorazine®, or Trilafon®. This medicine should not be given to a child who is under the age of two or who weighs less than 20 pounds, or who is having surgery

How to Use This Medicine:


  • Your doctor will prescribe your exact dose, and how often it should be given.
  • A nurse or other health provider will give you this medicine. This medicine may be given as a shot into a muscle or a vein.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
  • Make sure your doctor knows if you are also using a blood thinner (such as warfarin), or a diuretic ("water pill") such as hydrochlorothiazide (HCTZ). Tell your doctor if you take medicine to prevent seizures, such as phenytoin (Dilantin®). Make sure your doctor knows if you are using lithium (Eskalith®), or medicine for high blood pressure or heart problems such as propranolol (Inderal®). Your doctor should also know if you are taking certain medicines called alpha blockers, such as doxazosin (Cardura®), prazosin (Minipress®), or terazosin (Hytrin®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have a history of breast cancer. Tell your doctor if you have heart disease, blood pressure problems, circulation problems, or problems with your immune system. Make sure your doctor knows if you have Reye's syndrome, glaucoma, pheochromocytoma, or bone marrow disease.
  • This medicine may make you dizzy, drowsy, or less alert. Avoid driving, using machines, or doing anything else that requires you to be alert.
  • This medicine may make you more likely to become overheated in hot weather or during hard work or exercise.
  • If this medicine is for your child, make sure the doctor knows if your child has been sick recently, or if your child is dehydrated (not enough body fluids).
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for tests such as myelography.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Drooling, trouble swallowing, or trouble keeping your tongue in your mouth.
  • Fever, chills, body aches, sore throat, or cough.
  • Lightheadedness or fainting.
  • Muscle spasms, weakness, or stiffness.
  • Problems with balance or walking.
  • Redness, swelling, pain, or burning near the injection site.
  • Severe neck pain.
  • Severe sleepiness, trouble thinking clearly, or a change in your behavior.
  • Shaking, twitching, or muscle movements you cannot control, including jerky movement in your face, tongue, or jaw.
  • Skin changes or jaundice (yellowing of your skin or the whites of your eyes).
  • Trouble straightening or relaxing your neck, back, fingers, toes, or jaw.
  • Uneven, pounding, or fast heartbeat.
  • Unusual bleeding or bruising.

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision, dry eyes, or eyes more sensitive to light.
  • Feeling anxious, restless, or jittery, or being unable to sleep.
  • Missed menstrual period.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/4/2014
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
Copyright © 1984- Truven Health Analytics. All rights reserved.

Thomson & A.D.A.M