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Polymyxin B (Injection)

Polymyxin B Sulfate (pol-ee-MIX-in B SUL-fate)

Treats infections caused by bacteria. This medicine is an antibiotic.

Brand Name(s):

Novaplus Polymyxin B

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to polymyxin.

How to Use This Medicine:


  • A nurse or other trained health professional will give you this medicine.
  • This medicine is given as a shot into a muscle or a vein. It can also be given as a shot into your back.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using other medicine to treat infection such as amikacin, bacitracin, cephaloridine, colistin, gentamicin, kanamycin, neomycin, paromomycin, streptomycin, tobramycin, viomycin, Amikin®, or Garamcyin®.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease. Tell your doctor if you are taking or have recently taken another antibiotic. Tell your doctor if you have recently had surgery or a procedure that included the use of anesthesia.
  • Ask your doctor before you take any medicine to stop severe diarrhea.It may occur 2 months or more after you stop using this medicine.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision
  • Clumsiness, weakness, numbness, tingling feeling
  • Decrease in how much or how often you urinate, bloody or cloudy urine, trouble urinating
  • Diarrhea that may contain blood
  • Dizziness, drowsiness, or irritability
  • Fever with a headache or stiff neck
  • Trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Increased warmth or redness of the face
  • Redness, pain, swelling, or a lump under your skin where the shot was given
  • White spots in your mouth or throat, vaginal itching, or unusual vaginal discharge

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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