Conjugated estrogens (Injection)
Conjugated Estrogens (KON-joo-gay-ted ES-troe-jenz)
Treats abnormal bleeding from your uterus caused by a hormonal imbalance.
Premarin IntravenousThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not receive this medicine if you have had an angioedema or an allergic reaction to conjugated estrogens or if you are pregnant. You should not receive this medicine if you have liver disease, breast cancer, blood clotting problems, or a history of blood clots, heart attack, or stroke.
How to Use This Medicine:
- A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given into a vein or into a muscle.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- This medicine is not for long-term use.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use carbamazepine (Tegretol®), clarithromycin (Biaxin®), erythromycin (Ery-Tab®), itraconazole (Sporanox®), ketoconazole (Nizoral®), phenobarbital (Luminal®), rifampin (Rifadin®, Rifater®), ritonavir (Norvir®), St John's wort, or thyroid medicines.
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Make sure your doctor knows if you are breastfeeding, have endometriosis, or a history of cancer. Tell your doctor if you have kidney disease, edema, asthma, diabetes, epilepsy, gallbladder disease, lupus, migraine headaches, porphyria, thyroid problems, liver problems, or a family history of breast cancer or high cholesterol. Tell your doctor if you have heart disease, high blood pressure, or high or low calcium in the blood.
- This medicine may increase your risk of heart attack, stroke, or blood clots. Your risk for these serious problems is even greater if you have high blood pressure, high cholesterol, or diabetes. Your risk is also greater if you are overweight or smoke cigarettes. Talk to your doctor about your personal risks compared with the benefits of this medicine.
- This medicine may increase your risk of dementia (loss of some mental abilities, such as memory or judgment). Talk with your doctor about this risk.
- Long-term use of large doses of estrogens may increase your risk of some kinds of cancer, including breast cancer and cancer of the uterus. Ask your doctor if you have questions about your personal risks compared with the benefits of this medicine.
- Tell your doctor if you have a severe headache or vision changes. Your doctor may want you to have your eyes checked by an eye doctor.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.You may need to stop using this medicine for a few weeks before and after you have surgery or if you need to stay in bed for a long time.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.You should have regular pelvic exams, breast exams, and mammograms as directed by your doctor.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Breast lump
- Chest pain, trouble breathing, coughing up blood
- Numbness or weakness in your arm or leg, or on one side of your body
- Pain in your lower leg (calf)
- Sudden or severe headache, problems with vision, speech, or walking
- Swelling in your hands, ankles, or feet
- Sudden and severe stomach pain, nausea, vomiting
- Unusual or unexpected vaginal bleeding or heavy bleeding
- Vision changes
- Yellow skin or eyes
If you notice these less serious side effects, talk with your doctor:
- Mild nausea, vomiting, stomach cramps
- Pain, itching, swelling, or rash where the needle is placed
- Swollen or tender breasts
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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