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Rifaximin (By mouth)

Rifaximin (rif-AX-i-min)

Treats traveler's diarrhea caused by a bacteria called Escherichia coli. It is also used to prevent hepatic encephalopathy, which is a condition that occurs when your liver does not work normally. This is an antibiotic.

Brand Name(s):

Xifaxan

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to rifaximin, or similar drugs like rifampin (Rifadin®, Rimactane®) or rifabutin (Mycobutin®). You should not use this medicine if you or your child have diarrhea with blood, diarrhea and a fever, diarrhea that is not caused by Escherichia coli, or diarrhea that was caused by an antibiotic.

How to Use This Medicine:

Tablet

  • Take your medicine as directed.
  • You may take this medicine with or without food.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you or your child have recently been taking an antibiotic.
  • Call your doctor if your diarrhea gets worse or continues after using this medicine for 1 to 2 days. Check with your doctor right away if you or your child develop a fever or have blood in your stool.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever, chills, cough, sore throat, and body aches.
  • Rapid weight gain.
  • Shortness of breath.
  • Swelling of the hands, ankles, feet, or lower legs.
  • Unusual bleeding or bruising.
  • Unusual tiredness or weakness.
  • Upset stomach or pain in your upper stomach.

If you notice these less serious side effects, talk with your doctor:

  • Bloated, full feeling, or passing gas.
  • Constipation, nausea, or vomiting.
  • Dizziness.
  • Headache.
  • Muscle, joint, or back pain.
  • Skin rash or itching.
  • Trouble sleeping.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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