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Olanzapine/fluoxetine (By mouth)

Fluoxetine Hydrochloride (floo-OX-e-teen hye-droe-KLOR-ide), Olanzapine (oh-LAN-za-peen)

This medicine contains an SSRI, and it is used to treat depression.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to olanzapine or fluoxetine.

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • It is best to take this medicine in the evening.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine with pimozide or thioridazine. Do not use this medicine within 14 days of using an MAO inhibitor (MAOI), and do not start an MAOI for at least 5 weeks after you stop using fluoxetine.
  • Make sure your doctor knows if you are using St John's wort, tryptophan, buspirone, digitoxin, dolasetron, fentanyl, lithium, methadone, pentamidine, probucol, tacrolimus, tramadol, or vinblastine. Tell your doctor if you are taking a sedative or anxiety medicine, medicine to treat migraine headaches, an NSAID pain or arthritis medicine (such as aspirin, celecoxib, diclofenac, ibuprofen, naproxen), or a blood thinner (such as warfarin).
  • Tell your doctor if you are using other medicine to treat depression, medicine to treat mental illness, an antibiotic (such as erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), medicine to treat malaria (such as halofantrine, mefloquine), medicine for seizures (such as carbamazepine, phenytoin), a diuretic (water pill), or medicine for heart rhythm problems (such as amiodarone, flecainide, procainamide, propafenone, quinidine, sotalol).
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant, or if you have liver disease, bleeding problems, glaucoma, diabetes, high cholesterol, prostate problems, or a history of breast cancer, mania, seizures, or severe constipation. Make sure your doctor knows if you have had a heart rhythm problem, such as QT prolongation, or if you or a family member has had a heart attack, heart failure, low blood pressure, or a stroke.
  • Do not breastfeed while you are using this medicine.
  • This medicine may cause the following problems:
    • Serotonin syndrome
    • Heart rhythm changes
    • Higher risk of bleeding
    • Low sodium levels in the blood
    • Neuroleptic malignant syndrome, a nerve and muscle problem
    • High blood sugar, cholesterol, or triglyceride levels
    • Tardive dyskinesia, a muscle problem that may become permanent
  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or your family has a history of bipolar disorder or suicide attempts.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may make it more difficult for your body to cool down. Be careful to not become overheated during exercise or hot weather, because you could have heat stroke.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Confusion, weakness, and muscle stiffness or twitching
  • Fast, pounding, or uneven heartbeat
  • Feeling very thirsty or hungry, change in how much or how often you urinate
  • Fever, chills, cough, sore throat, and body aches
  • Fever, sweating, confusion, uneven heartbeat, muscle stiffness
  • Jerky muscle movement you cannot control (often in your face, tongue, or jaw)
  • Lightheadedness, dizziness, or fainting
  • Seizures
  • Trouble sleeping, unusual dreams
  • Unusual behavior, thoughts of hurting yourself or others
  • Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

  • Sexual problems
  • Sleepiness or unusual drowsiness
  • Trouble swallowing
  • Weight gain, increased appetite

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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