Conjugated estrogens/medroxyprogesterone (By mouth)
Conjugated Estrogens (KON-joo-gay-ted ES-troe-jenz), Medroxyprogesterone Acetate (me-drox-ee-proe-JES-ter-one AS-e-tate)
Treats menopause symptoms (hot flashes, vaginal dryness). Prevents osteoporosis after menopause. This medicine is a combination of 2 hormones.
Premphase, Prempro, Prempro Low DoseThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to estrogen or progestin, or if you have had a hysterectomy. You should not use this medicine if you have a history of liver disease, breast cancer, blood clots or clotting problems, heart attack, or stroke. Do not use this medicine if you are pregnant or have unusual vaginal bleeding that your doctor has not checked.
How to Use This Medicine:
- Take your medicine as directed.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
If a dose is missed:
- Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using medicine to treat an infection (such as clarithromycin, erythromycin, itraconazole, ketoconazole, Biaxin®, Nizoral®, or Sporanox®), medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Luminal®, or Tegretol®), medicine to treat depression (such as nefazodone, Serzone®), aminoglutethimide (Cytadren®), rifampin (Rifadin®, Rimactane®), ritonavir (Norvir®), or St. John's wort.
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Make sure your doctor knows if you are breastfeeding, have endometriosis, or a history of cancer. Tell your doctor if you have asthma, diabetes, epilepsy, heart failure, high blood pressure, high cholesterol, high or low calcium in the blood, kidney disease, lupus, migraine headaches, porphyria, or thyroid problems. Tell your doctor if you have had serious allergic reactions (such as hereditary angioedema).
- Your risk of heart attack, stroke, blood clots, or dementia may increase while using this medicine. Talk with your doctor about this risk. Your risk of blood clots or stroke from this medicine is higher if you smoke. Your risk is also increased if you have diabetes or high cholesterol, or if you are overweight.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine before you have surgery or if you need to be on bedrest. This medicine may affect the results of certain medical tests.
- Long-term use of large doses of estrogens may increase your risk of some kinds of cancer, including breast cancer. You should examine your breasts at home every month, and your doctor should examine your breasts for lumps once every year. Ask your doctor if you do not know how to perform a breast self-examination.
- Tell your doctor if you have a severe headache or vision changes with this medicine. Your doctor may want you to have your eyes checked by an eye doctor.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Breast lumps
- Chest pain, shortness of breath, or coughing up blood
- Numbness or weakness in your arm or leg, or on one side of your body
- Pain in your lower leg (calf)
- Problems with vision, speech, or walking
- Severe or unusual vaginal bleeding
- Sudden and severe stomach pain, with or without nausea, vomiting, fever, and lightheadedness
- Sudden or severe headache
- Swelling in your face, hands, ankles, or feet
- Yellowing of your skin or the whites of your eyes
If you notice these less serious side effects, talk with your doctor:
- Breast pain
- Light vaginal bleeding or spotting
- Mild stomach pain, cramps, or gas
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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