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Oxycodone, slow release (By mouth)

Oxycodone Hydrochloride (ox-i-KOE-done hye-droe-KLOR-ide)

Treats moderate to severe pain when around-the-clock pain relief is needed for a long period of time. Slow-release oxycodone is a narcotic medicine that should not be taken more often than every 12 hours.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to oxycodone, codeine, dihydrocodeine, hydrocodone, or morphine. Do not use this medicine if you are breastfeeding, or if you have serious breathing problems, paralytic ileus, or stomach or bowel blockage.

How to Use This Medicine:

Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • An overdose can be dangerous. Follow these directions carefully so you do not get too much medicine at one time.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.Do not take any tablet that is chipped or broken.
  • Do not soak, lick, or wet the tablet before you place it in your mouth. Take 1 tablet at a time with enough water to swallow it completely.
  • You may take this medicine with food or milk if it upsets your stomach.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • This medicine can cause serious side effects if taken by anyone who is not used to narcotic pain medicines. Store the medicine in a safe and secure place to prevent others from getting it. Keep it away from pets.
  • Do not throw any unused medicine in the trash. Flush it down the toilet, or take it to a community take-back program if available.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine. Make sure your doctor knows if you are also using butorphanol (Stadol®), nalbuphine (Nubain®), pentazocine (Talwin®), or a muscle relaxer (such as carisoprodol, cyclobenzaprine, metaxalone, methocarbamol, Skelaxin®, Soma®).
  • Tell your doctor if you use a phenothiazine medicine such as promethazine, Phenergan®, or Thorazine®. These medicines may be used to treat severe vomiting, coughing, psychiatric problems, or other conditions.
  • Tell your doctor if you are also using medicine to treat an infection (such as clarithromycin, erythromycin, itraconazole, ketoconazole, voriconazole, Nizoral®), medicine to treat HIV/AIDS (such as atazanavir, lopinavir, ritonavir, Crixivan®, Kaletra®, Lexiva®, Norvir®, Prezista®, Reyataz®), medicine to treat seizures (such as carbamazepine, phenytoin, Dilantin®, Tegretol®), medicine to treat tuberculosis (such as rifampin, Rifadin®, Rimactane®), or a diuretic (water pill, such as furosemide, hydrochlorothiazide, torsemide, Lasix®).
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or if you have kidney disease, liver disease, breathing problems or lung disease (such as COPD), low blood pressure, trouble urinating, underactive thyroid, Addison disease, or prostate problems. Tell your doctor if you have digestion problems, including esophagus cancer, colon cancer, or pancreas problems. Tell your doctor if you have a history of head injury, brain lesion, depression, seizures, or alcohol or drug abuse.
  • Do not use more of this medicine or take it more often than your doctor tells you to. This can be life-threatening. Symptoms of an overdose include extreme dizziness or weakness, slow heartbeat, slow breathing, trouble breathing, seizures, and cold, clammy skin. Call your doctor right away if you have these symptoms.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make you feel dizzy, drowsy, or faint. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly. Lie down if needed until you feel better.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blue lips, fingernails, or skin
  • Extreme weakness, shallow breathing, uneven heartbeat, sweating, cold or clammy skin
  • Seizures
  • Severe confusion, lightheadedness, dizziness, or fainting
  • Severe constipation or vomiting
  • Trouble breathing or slow breathing

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth
  • Headache
  • Itching skin
  • Mild constipation, nausea, vomiting
  • Sleepiness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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